DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp10 and alpl

DIOPT Version :9

Sequence 1:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_031762314.1	Gene:	alpl / 100485467	XenbaseID:	XB-GENE-1010301	Length:	527	Species:	Xenopus tropicalis

Alignment Length:	489	Identity:	220/489 - (44%)
Similarity:	286/489 - (58%)	Gaps:	35/489 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DEELDTRFWHDKAQSILADKLAGHKKLNENRAKNVILFLGDGMSVHTIAATRAFMGD------SN 102
            ::|.|.::|..:||..|.|.|...:.||.|.|||||:||||||.|.|:.|||...|.      ..
Frog    21 EQEKDPKYWRRQAQDTLRDALLLLQNLNTNVAKNVIMFLGDGMGVPTVTATRILKGQMAGQPGEE 85

  Fly   103 KQVFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNAQVQRGDCVTNSSSHVQS 167
            .|:..:|||::.|||||..|.:.||||.||||||.|||||.||:||||...||.|.|...:.|.|
Frog    86 TQLEMDKFPHVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVNAAAVRGQCNTTRGNEVDS 150

  Fly   168 IGQWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHD----GEIISSKCSPDVNTDIARQLV 228
            |.:||::|||..|:|||.|:.||:|:..|||...|:|..|    .|.:...|.     |||.||:
Frog   151 ILKWAKQAGKSVGVVTTTRINHATPSAAYAHCVNRDWYSDLEMPKEAVEQGCK-----DIAWQLM 210

  Fly   229 -EWPVGQELRVIMGGGRSYFRDQSQHD-----ETGVSGLRTDGRDLISDWREIKKQQGAEGKYVW 287
             ..|   .:.|||||||.|...::..|     :...||.|.||.:|...|.:.|..:.| .:|||
Frog   211 HNVP---NIEVIMGGGRKYMYPRNTSDVEYPNDDKASGTRLDGLNLTQIWLDQKPNKQA-ARYVW 271

  Fly   288 SLKGLKETDISKTDYLLGLFDTSHLPYHGDRRRTHYEDAEPSLSDMTEAAIKMLSKNEEGYFLFV 352
            :.:.|...:..:.|:|||||:...:.|..:|..|    .:|||.:|.|.|||:|.||.||:||.|
Frog   272 NRQQLLSVNPQEVDHLLGLFEPIDMLYELERNTT----MDPSLPEMVEMAIKILRKNPEGFFLLV 332

  Fly   353 ESGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSINGYPYRRQNIL 417
            |.||||..||..||.:||.:..:...|:.||..||.|||||.|||:||||..:..||.:|..:|.
Frog   333 EGGRIDHGHHEGKANQALHEAVQMDIAIGLAGSMTSEEDTLTVVTADHSHVFTFGGYTHRGTSIF 397

  Fly   418 SLAPNLAD-DELPFTILSYANGPGFDDTYSTKDG-RIDLSHADTTSAEFEFQATVPLSSETHGAE 480
            .|||.::| |:.|||.:.|.||||    |...:| |.::|..|.:...:..|:.|||..||||.|
Frog   398 GLAPAVSDVDQKPFTSILYGNGPG----YKLVNGQRENVSTVDFSHPNYLAQSAVPLRMETHGGE 458

  Fly   481 DVGVFASGPFEHLFTGNYEQSAIPAMMAYAANIG 514
            ||.|||.||..||..|.:||:.||.:|||||.||
Frog   459 DVAVFAKGPMAHLLHGVHEQNYIPHVMAYAACIG 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	212/471 (45%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	205/453 (45%)
alpl	XP_031762314.1	Alk_phosphatase	52..491	CDD:395188	207/455 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm9329
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.030