DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp10 and Alpp

DIOPT Version :9

Sequence 1:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_002730104.3	Gene:	Alpp / 100359675	RGDID:	2325055	Length:	529	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	201/498 - (40%)
Similarity:	289/498 - (58%)	Gaps:	36/498 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LQSSRDFEALDEELDTRFWHDKAQSILADKLAGHKKLN--ENRAKNVILFLGDGMSVHTIAATRA 96
            ||.|.....::|| :..||:.||    |:.|...|||.  :..|.|:|:.:||||.|.|:.|||.
  Rat    13 LQMSLSLVPVEEE-NPAFWNRKA----AEALEAAKKLQPIQTSANNLIILMGDGMGVSTVTATRI 72

  Fly    97 FMGDS------NKQVFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNAQVQRG 155
            ..|..      ...:..::||::.|||||..:::.||||.|.||:|.|||.|...||::|..:..
  Rat    73 LKGQQQGHLGPETPLAMDRFPHMALSKTYNTDKQVPDSAGTGTAFLCGVKTNMKVIGLSAAARFN 137

  Fly   156 DCVTNSSSHVQSIGQWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEIISSKCSPDVN 220
            .|.|...:.|.|:...|::|||..|:|||..|.||||||.|||...|||..|.. :|:....:..
  Rat   138 QCNTTWGNEVVSVMHRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNRNWYSDAH-MSTAALQEGC 201

  Fly   221 TDIARQLVEWPVGQELRVIMGGGRSYF-----RDQSQHDETGVSGLRTDGRDLISDWREIKKQQG 280
            .|||.||:.   ..::.||:||||.:.     .||....:...:|.|.|||:|:.:|  :.|.||
  Rat   202 KDIAMQLIS---NTDIDVILGGGRKFMFPKGTPDQEYPTDPQQAGTRLDGRNLVQEW--LAKHQG 261

  Fly   281 AEGKYVWSLKGLKETDISKT-DYLLGLFDTSHLPYHGDRRRTHYEDAEPSLSDMTEAAIKMLSKN 344
            |:  |||:...|.:..:::: .:|:|||:.:.:.|:.||..|.    :|||::|||.|:.|||:|
  Rat   262 AQ--YVWNRTELIQASLNRSVTHLMGLFEPNDMKYNIDRDPTQ----DPSLAEMTEVAVHMLSRN 320

  Fly   345 EEGYFLFVESGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSINGY 409
            .:|::||||.||||..||...|.:||.:...|.:||:.|.|:|.|:||:|:||:||||..|..||
  Rat   321 PKGFYLFVEGGRIDHGHHEAIAYRALTEAVMFDSAVDKADKLTSEKDTMIIVTADHSHVFSFGGY 385

  Fly   410 PYRRQNILSLAPNLADDELPFTILSYANGPGFDDTYSTKDG-RIDLSHADTTSAEFEFQATVPLS 473
            ..|..:|..|||..|.|...||.:.|.||||    |...:| |.|::..::::..::.||.||||
  Rat   386 TQREASIFGLAPFKAGDGKSFTSILYGNGPG----YKLNNGIRADVTEEESSNPTYQQQAAVPLS 446

  Fly   474 SETHGAEDVGVFASGPFEHLFTGNYEQSAIPAMMAYAANIGPF 516
            ||||..|||.:||.||..||..|..||:.|..:||:|..:.|:
  Rat   447 SETHSGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPY 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	191/468 (41%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	185/448 (41%)
Alpp	XP_002730104.3	Alk_phosphatase	51..486	CDD:395188	186/450 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351433
Domainoid	1	1.000	373	1.000	Domainoid score	I856
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1947
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8918
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910