DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp10 and alp3

DIOPT Version :9

Sequence 1:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001265768.1	Gene:	alp3 / 100330410	ZFINID:	ZDB-GENE-120919-1	Length:	534	Species:	Danio rerio

Alignment Length:	481	Identity:	214/481 - (44%)
Similarity:	286/481 - (59%)	Gaps:	26/481 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EELDTRFWHDKAQSILADKLAGHKKLNENRAKNVILFLGDGMSVHTIAATRAFMGDSNKQ----- 104
            ||.:..||...||:.|...|:  :|:|.|.|||::|||||||.|.||.|.|...|...|.
Zfish    21 EEENPEFWRKSAQNTLRSALS--RKINTNVAKNIVLFLGDGMGVTTITAARILKGQLQKHSGEET 83

  Fly   105 -VFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNAQVQRGDCVTNSSSHVQSI 168
             :..:.||.:||:|.|:|:.:.||||.||||||.|||.|..|:||:|..:.|.|.:...:.|.||
Zfish    84 VMNMDTFPNVGLAKVYSVDFQIPDSAATATAYLCGVKTNLNTVGVSAAARNGVCRSQKGNEVTSI 148

  Fly   169 GQWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEIISSKCSPDVNTDIARQLVEWPVG 233
            .:||::|||..|:|||.||.||:||..:||.:.|.|..|.::.:|..:... .|||.||:.   .
Zfish   149 LRWAKDAGKSVGIVTTTRVQHATPAASFAHSASRTWYSDADLPASAATEGC-VDIATQLLH---N 209

  Fly   234 QELRVIMGGGRSY-----FRDQSQHDETGVSGLRTDGRDLISDWREIKKQQGAEGKYVWSLKGLK 293
            .::.||:||||.|     |.|.....:....|.|.|||:||.||  |:.::|...:|||:.....
Zfish   210 IDIDVIIGGGRKYMTPKGFPDPEYPSDASAQGQRRDGRNLIQDW--IQMKEGKVARYVWNKTDFD 272

  Fly   294 ETDISKTDYLLGLFDTSHLPYHGDRRRTHYEDAEPSLSDMTEAAIKMLSKNEEGYFLFVESGRID 358
            ..|..|||||:.||:.:.|.:  |..|.|..|  ||:|:.|:.||::|.||.:|:||.||.||||
Zfish   273 AVDPEKTDYLMALFEPADLRF--DVERDHSMD--PSISETTDKAIQILKKNPKGFFLLVEGGRID 333

  Fly   359 MAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSINGYPYRRQNILSLAPNL 423
            ..||:::|..||.:......||....::||||:||.:||:||||..:.||||:|..:||..:|..
Zfish   334 QGHHSSRASAALHEAVALDEAVSRGLELTDEEETLTIVTADHSHAFTFNGYPFRGNSILGKSPIF 398

  Fly   424 ADDELPFTILSYANGPGFDDTYSTKDGRIDLSHADTTSAEFEFQATVPLSSETHGAEDVGVFASG 488
            |.|.||:|.|.|.||||..   .|.:.|.|:...||...::..|:.|||.|||||.|||.|||.|
Zfish   399 ASDFLPYTTLMYGNGPGHK---ITNNKRPDIRKVDTADKDYIQQSAVPLDSETHGGEDVAVFARG 460

  Fly   489 PFEHLFTGNYEQSAIPAMMAYAANIG 514
            |..|||.|.|||:.||..|||||.||
Zfish   461 PMAHLFQGVYEQNYIPHAMAYAACIG 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	205/464 (44%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	199/446 (45%)
alp3	NP_001265768.1	PhoA	30..482	CDD:224699	205/466 (44%)
alp3	NP_001265768.1	Alk_phosphatase	49..485	CDD:278666	201/448 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593219
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2001
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm6481
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17354
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940