DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and cyp17a2

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001099140.1	Gene:	cyp17a2 / 796487	ZFINID:	ZDB-GENE-100822-1	Length:	495	Species:	Danio rerio

Alignment Length:	549	Identity:	153/549 - (27%)
Similarity:	254/549 - (46%)	Gaps:	82/549 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YTILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGN-LHLL 70
            ::.|.:||.:|.           ||:|:.|   .|:.::....        || .|::|: |||
Zfish    10 FSALLLLLLLLV-----------RRLLEGV---GSSSVSFPCL--------PR-LPLLGSLLHL- 50

  Fly    71 DRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKLFG 135
             |....|...||.|:.|||.::.|..|....|||:.:.|:||||.|.|:..:|||..:....|..
Zfish    51 -RSNLPPHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQ 114

  Fly   136 GERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLVPGEPIN 200
            |  ...:|..|:|.|.:..|.|.  |.|...|.....|:..|..|..:....||  |...|:..:
Zfish   115 G--GKDIAFADYSPLWKNHRRLV--HSSFTLFGEGSNKLQTIVQEAADSLCEEL--QACRGQSSD 173

  Fly   201 IKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHPLDFLPWLYPFYQRHLNK 265
            :..::::|..|:..:.:.|..:...|.:.|.::||.|.|...|.:|..:|..|||..|..:.|.:
Zfish   174 LSVVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRIFPNKDLKR 238

  Fly   266 IINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALL----------KSLLEDKDVSRNTIIFM 320
            :....|.....:.::::.|:: |:...|| ||..||||          ..:.||     :.::..
Zfish   239 LKECVSIRDQLLYKKLLEHKK-SLTPGEP-RDLLDALLIGQQRGSGGADDITED-----HVLMTA 296

  Fly   321 LEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDMNAMPYTMATIFEV 385
            .|.|..|.......::..:|::..:..:..|:|.|:|..:..: |...|.|...:|...|.:.||
Zfish   297 AEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVD-RPPCLSDRPHLPLLDAVLCEV 360

  Fly   386 LRYSS-SPI-VPHVATEDTVISGYGVTKGTIVFINNYVLNTSEKFWVNPKEFNPLRFLEPSKEQS 448
            :|... ||| :||||.:||.:.|:.|.|||.|.:|.:.::...|.|..|::|||.||||||.::.
Zfish   361 MRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPERFLEPSGKKK 425

  Fly   449 PKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVVVNVMQRYNISSHNP 513
            .::|                      ||||..|.|.|:|::|.|...||.|...:||::.|..:.
Zfish   426 TQSS----------------------FLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPSE 468

  Fly   514 STIKISPE-----SLALPADCFPLVLTPR 537
            :::   |:     .:.|..:.:.:.:|||
Zfish   469 ASL---PDLQGRFGVVLQPERYTVTVTPR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	144/500 (29%)
cyp17a2	NP_001099140.1	p450	55..491	CDD:278495	133/474 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H107154
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910