DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and cyp21a2

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_021322557.1	Gene:	cyp21a2 / 793249	ZFINID:	ZDB-GENE-070103-6	Length:	522	Species:	Danio rerio

Alignment Length:	578	Identity:	142/578 - (24%)
Similarity:	241/578 - (41%)	Gaps:	111/578 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLSVLATSYICIIYGVK------RRVLQPVKTKNSTE-----INHNAYQKY--TQAP---GPRPW 61
            ::||:...:|..:..||      ||.....|..|..|     :.|:.|:.:  |.:|   |||..
Zfish     5 VVSVVLLLFILWMLVVKFRRQSHRRTDGVAKENNKPEAVFPKLLHSLYKLFFSTVSPTISGPRSL 69

  Fly    62 PIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPD 126
            |::||  :||..:|......||||:.||:||.|..|.|..:|:||.|:|||.|.:.....:|||
Zfish    70 PLLGN--MLDLAQDHLPIHLTALAKCYGNIYRLNCGSTTMVVLNNSEIIREALVKKWSDFAGRP- 131

  Fly   127 FIRYHKLFG-----GERSNSLALCDWSQLQQKRRNL---ARRHCSPREFSCFYMKMSQIGCEEME 183
                |...|     |.|:.||.  |:|:..:..|.:   |.:.|:.........|.:|..|:.:.
Zfish   132 ----HSYTGDIVSRGGRTISLG--DFSEEWKAHRRVTHSALQRCTTDSLHSVIEKQAQHLCQVLR 190

  Fly   184 HWNRELGNQLVPGEPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEI--FWEINQG 246
            .::         |:.:::......|.:|:.:....|..:|....:.|::.:..:||  .|    |
Zfish   191 DYS---------GKAVDLSEDFTVASSNVITTLTFSKAYDKSSAELQKLQECLNEIVSLW----G 242

  Fly   247 HP----LDFLPWLYPF----YQRHLNKIINWSSTIRGFIME-RIIRHRELSVDLDEPDRDFTDAL 302
            .|    ||..|.|..|    :.|.:.::......|...|.| :...|:|        ....|.:|
Zfish   243 SPWISALDSFPLLRKFPNPPFSRLMKEVARRDELIGKHIEEFKKSEHKE--------GGTLTSSL 299

  Fly   303 LKSL-----------LEDKDVSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEI 356
            ||.|           |.|..|...|:..:    |||...:..|:...:|::....::..::.||:
Zfish   300 LKCLEPQQGAANHTTLTDTHVHMTTVDLL----IGGTETIAALLNWTVAFLLHRPEVQDKVYEEL 360

  Fly   357 DAIIEEENRSINLLDMNAMPYTMATIFEVLRYSS-SPI-VPHVATEDTVISGYGVTKGTIVFINN 419
            ..:::..:...:  |.:.:||..|.|.|:||... :|: |||.|..::.|:|:.:.|.||:..|.
Zfish   361 CCMLDVRHPQYS--DRHKLPYLCALISEMLRLRPVAPLAVPHRAIRNSSIAGHFIPKNTIIIPNL 423

  Fly   420 YVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRT 484
            |..:...:.|.:|..|.|.||||           |....:.|             .:||..|.|.
Zfish   424 YGAHHDPEVWDDPYSFKPERFLE-----------GGGGSLRS-------------LIPFGGGARL 464

  Fly   485 CIGQNLVRGFGFLVVVNVMQRYNI---SSHNPSTIKISPESLALPADCFPLVLTPREK 539
            |:|:.:.:...||....:::.:..   |...|........|:.|....:.::..|||:
Zfish   465 CLGEAVAKMEMFLFTAYLLREFKFLPASKEEPLPELRGVASVVLKVKPYTVIAHPREQ 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	129/522 (25%)
cyp21a2	XP_021322557.1	p450	64..516	CDD:306555	125/511 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000