DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2d26

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_083838.1	Gene:	Cyp2d26 / 76279	MGIID:	1923529	Length:	500	Species:	Mus musculus

Alignment Length:	574	Identity:	149/574 - (25%)
Similarity:	240/574 - (41%)	Gaps:	136/574 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AALIYTILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQA--PGPRPWPIIG 65
            |.:|:|.:.:||..|          |.||                  |::|..  |||.|:|.:|
Mouse    11 AVVIFTAIFLLLVDL----------VHRR------------------QRWTACYPPGPVPFPGLG 47

  Fly    66 NLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRY 130
            ||..:| :.:.|:: |..|..:||:::||.......:|||.|:.:||:|...|:..|.||....|
Mouse    48 NLLQVD-FENIPYS-FYKLQNRYGNVFSLQMAWKPVVVVNGLKAVRELLVTYGEDTSDRPLMPIY 110

  Fly   131 HKLFGGERSNSLALC----DWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGN 191
            :.:..|.:|..:.|.    :|.:              .|.||...::...:|.:.:|.|..|...
Mouse   111 NHIGYGHKSKGVILAPYGPEWRE--------------QRRFSVSTLRDFGLGKKSLEQWVTEEAG 161

  Fly   192 QLVPG------EPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEIN--QGHP 248
            .|...      .|.|..||:.||.:|:.:..:.:.||:|:|..|.::::...|...|..  .|..
Mouse   162 HLCDAFTKEAEHPFNPSPLLSKAVSNVIASLIYARRFEYEDPFFNRMLKTLKESLGEDTGFVGEV 226

  Fly   249 LDFLPWL----------YPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALL 303
            |:.:|.|          :|    .||..|       ..:.:.:|.| :.:.|..:|.||.|||.|
Mouse   227 LNAIPMLLHIPGLPDKAFP----KLNSFI-------ALVNKMLIEH-DSTWDPAQPPRDLTDAFL 279

  Fly   304 ----------KSLLEDKDVSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDA 358
                      :|...||    |..|.:::.|:.|.......:...|..:..:.|:.||:.:|||.
Mouse   280 AEVEKAKGNPESSFNDK----NLRIVVIDLFMAGMVTTSTTLSWALLLMILHPDVQRRVHQEIDE 340

  Fly   359 IIEEENRSINLLDMNAMPYTMATIFEVLRYSSSPIV----PHVATEDTVISGYGVTKGTIVFINN 419
            :|... |...:.|...||||.|.|.||.|::.  ||    ||:.:.|.....:.:.|||.:..|.
Mouse   341 VIGHV-RHPEMADQARMPYTNAVIHEVQRFAD--IVPTNLPHMTSRDIKFQDFFIPKGTTLIPNL 402

  Fly   420 YVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPH--FLPFSIGK 482
            ..:...|..|..|..|.|..||:         ::|               ..:.|  |:|||.|:
Mouse   403 SSVLKDETVWEKPLRFYPEHFLD---------AQG---------------HFVKHEAFMPFSAGR 443

  Fly   483 RTCIGQNLVRGFGFLVVVNVMQRYNIS----SHNPS-----TIKISPESLALPA 527
            |:|:|:.|.|...||....::||::.|    ...||     |:.::||...|.|
Mouse   444 RSCLGEPLARMELFLFFTCLLQRFSFSVPDGQPRPSDYGIYTMPVTPEPYQLCA 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	138/519 (27%)
Cyp2d26	NP_083838.1	p450	37..496	CDD:278495	136/517 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920