DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2j9

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_083255.1	Gene:	Cyp2j9 / 74519	MGIID:	1921769	Length:	502	Species:	Mus musculus

Alignment Length:	563	Identity:	154/563 - (27%)
Similarity:	228/563 - (40%)	Gaps:	127/563 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLAA---LIYTILAIL-LSVLATSYICIIY---GVKRRVLQPVKTKNSTEINHNAYQKYTQAPGP 58
            ||||   |:..|.|.| |.:|..|.:..::   .:|.|     :.||             ..|||
Mouse     1 MLAAAGSLVAAIWAALHLRILLLSAVTFLFLADFLKNR-----RPKN-------------YPPGP 47

  Fly    59 RPWPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSG 123
            ...|.:|.|..||  ...|........::||::.||.|.:...:|:..:.||:|:..|.......
Mouse    48 MRLPFVGCLFHLD--PKQPHLSLQQFVKKYGNVLSLDFANIPSVVITGMPLIKEIFTQMEHNFMN 110

  Fly   124 RP-DFIRYHKLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNR 187
            || ..:|.| ||   ..|.|........:::||           |:...::...:|...:|...:
Mouse   111 RPVTLLRKH-LF---NKNGLIFSSDQTWKEQRR-----------FALMTLRNFGLGKRSLEERIQ 160

  Fly   188 ELGNQLVP------GEP----INIKPLILKACANMFSQYMCSL----RFDYDDVDFQQIVQYFDE 238
            |..:.||.      |:|    .||        :|..|..:||:    ||||.|..||::::..||
Mouse   161 EEAHYLVEAIRDEGGQPFDPHFNI--------SNAVSNIICSITFGERFDYHDSQFQEMLRLLDE 217

  Fly   239 --------------IFWEINQGHPLDFLPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSV 289
                          ||..|     |.:||      ..|.....||.. ::.|:.:.:..||. ..
Mouse   218 AMCLESSMMCQLYNIFPRI-----LQYLP------GSHQTLFRNWRK-LQLFVSDIVNNHRR-DW 269

  Fly   290 DLDEPDRDFTDALLKSLLE--DKDVS----RNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDI 348
            |.||| |||.||.|..:.:  ||..:    .|.|...|:.|..|.......:...|..:|...::
Mouse   270 DPDEP-RDFIDAFLTEMTKYPDKTTTSFNEENLICSTLDLFFAGTETTSTTLRWALLCMALYPEV 333

  Fly   349 GRRIQEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYSS-SPI-VPHVATEDTVISGYGVTK 411
            ..::|.|||.:|.:. |..||.|.::||||.|.|.||.|..: .|. ||.....||.::|:.:.|
Mouse   334 QEKMQAEIDRVIGQA-RQPNLADRDSMPYTNAVIHEVQRMGNIIPFNVPREVAVDTQLAGFNLPK 397

  Fly   412 GTIVFINNYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFL 476
            |.:|..|...|:.....|..|..|||..|||..                      |.|:. ..||
Mouse   398 GIMVLSNLTALHRDPSEWTTPDTFNPEHFLENG----------------------QFKKR-ESFL 439

  Fly   477 PFSIGKRTCIGQNLVRGFGFLVVVNVMQRYNISSHNPSTIKIS 519
            |||:|||.|:|:.|.|...|:.:..:.|::....  |...|:|
Mouse   440 PFSMGKRACLGEQLARSELFIFITTLFQKFTFKP--PVNEKLS 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	139/501 (28%)
Cyp2j9	NP_083255.1	p450	44..497	CDD:278495	139/502 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010