DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2s1

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_083051.1	Gene:	Cyp2s1 / 74134	MGIID:	1921384	Length:	501	Species:	Mus musculus

Alignment Length:	572	Identity:	138/572 - (24%)
Similarity:	235/572 - (41%)	Gaps:	123/572 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ALIYTILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLH 68
            ||:..:|.:||.:..|     ::....|...|                    |||.|.|::||
Mouse     8 ALLLALLLLLLLLSLT-----LFRTPARGYLP--------------------PGPTPLPLLGN-- 45

  Fly    69 LLDRYRDSPFAGFTALAQQYGDIYSLTFG-HTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHK 132
            ||.....:.::|...|:::||.::::..| ..|.:|:...:.:||.|....:..|||.......|
Mouse    46 LLQLRPGALYSGLLRLSKKYGPVFTVYLGPWRRVVVLVGHDAVREALGGQAEEFSGRGTLATLDK 110

  Fly   133 LF--------GGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNREL 189
            .|        .|||        |.||              |:|:...::...:|..|.|...:..
Mouse   111 TFDGHGVFFANGER--------WKQL--------------RKFTLLALRDLGMGKREGEELIQAE 153

  Fly   190 GNQLV------PGEPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQ--G 246
            ...||      .|.|.|...|:.:|.:|:....:..:|..|||.:||.::|........|:.  |
Mouse   154 VQSLVEAFQKTEGRPFNPSMLLAQATSNVVCSLVFGIRLPYDDKEFQAVIQAASGTLLGISSPWG 218

  Fly   247 HPLDFLPWL-------YPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLK 304
            ...:...||       :...|.||       .|:..|.::::.:|:. ......|.||..||.|.
Mouse   219 QAYEMFSWLLQPLPGPHTQLQHHL-------GTLAAFTIQQVQKHQG-RFQTSGPARDVVDAFLL 275

  Fly   305 SLLEDKD------VSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEE- 362
            .:.::|.      ..:|.::.:......|...:|..:...|..:.:...:.:|::||   :|:|
Mouse   276 KMAQEKQDPGTEFTEKNLLMTVTYLLFAGTMTIGATIRYALLLLLRYPQVQQRVREE---LIQEL 337

  Fly   363 -ENRSINLLDMNAMPYTMATIFEVLR-YSSSPI-VPHVATEDTVISGYGVTKGTIVF-INNYVLN 423
             ..|:.:|.|...:|||.|.:.|..| .:..|: :||..|..|...||.:.|||.|| :...:|:
Mouse   338 GPGRAPSLSDRVRLPYTDAVLHEAQRLLALVPMGMPHTITRTTCFRGYTLPKGTEVFPLIGSILH 402

  Fly   424 TSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQ 488
            ....| .||.||:|.|||:                     |..:|::: ..|||:|:|||.|:|:
Mouse   403 DPAVF-QNPGEFHPGRFLD---------------------EDGRLRKH-EAFLPYSLGKRVCLGE 444

  Fly   489 NLVRGFGFLVVVNVMQRYNISSH-NPSTIKISPESLAL---PADCFPLVLTP 536
            .|.|...:|...:::|.:::.:. .|..:.:.|....|   |.| |.|.:.|
Mouse   445 GLARAELWLFFTSILQAFSLETPCPPGDLSLKPAISGLFNIPPD-FQLRVWP 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	130/520 (25%)
Cyp2s1	NP_083051.1	p450	50..487	CDD:365848	116/492 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010