DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2c65

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_082467.2	Gene:	Cyp2c65 / 72303	MGIID:	1919553	Length:	490	Species:	Mus musculus

Alignment Length:	560	Identity:	141/560 - (25%)
Similarity:	239/560 - (42%)	Gaps:	122/560 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHLLDRY 73
            :|.:.|.:|.|   |::       |..:..:||        |:....|||.|.|||||:..||..
Mouse     2 VLGVFLGLLLT---CLL-------LLSLWRQNS--------QRRNLPPGPTPLPIIGNILQLDLK 48

  Fly    74 RDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGR---PDFIRYHK--- 132
            ..|  ......::.||.:::|..|....:|::..|.::|....:|:..:||   |.|.::.|
Mouse    49 DIS--KSLRNFSKVYGPVFTLYLGRNPAVVLHGYEAVKEAFTDHGEEFAGRGVFPVFDKFKKNCG 111

  Fly   133 -LFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLV-- 194
             :|...|:       |.::              |.||...::...:|...:|...:|....||
Mouse   112 VVFSSGRT-------WKEM--------------RRFSLMTLRNFGMGRRSIEDRIQEEARCLVDE 155

  Fly   195 ----PGEPINIKPLILKACA--NMFSQYMCSLRFDYDDVDFQQIVQYFDEIF------W-EINQG 246
                .|||.:  |..:..||  |:....:...||||.|.:|...:...:|..      | :|...
Mouse   156 LRKTKGEPCD--PTFILGCAPCNVICSIVFQNRFDYKDQEFLTFLDILNENVEILSSPWIQICNN 218

  Fly   247 HP--LDFLPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLKSLLED 309
            .|  :|:||..:    |.|:|...::   ..:.:.::.:|:| |:|::.| |||.|..|..:.::
Mouse   219 FPAVIDYLPGRH----RKLHKNFAFA---EHYFLSKVKQHQE-SLDINNP-RDFIDCFLIKMEQE 274

  Fly   310 K-----DVSRNTIIFMLED-FIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSIN 368
            |     :.:...::|...| |..|.......:...|..:.|..::..::|||||.:| ..:||..
Mouse   275 KHNPKTEFTCENLVFTASDLFAAGTETTSTTLRYSLLLLLKYPEVTAKVQEEIDCVI-GRHRSPC 338

  Fly   369 LLDMNAMPYTMATIFEVLRYSS--SPIVPHVATEDTVISGYGVTKGTIVFINNYVLNTSEKFWVN 431
            :.|.::||||.|.:.|:.||..  ...:||..|.|.....|.:.|||.|..:...:...:|.:.|
Mouse   339 MQDRHSMPYTDAVLHEIQRYIDLLPTSLPHAVTRDVKFREYLIPKGTTVIASLTSVLYDDKEFPN 403

  Fly   432 PKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGF 496
            |::|:|..||:                     |:.:.|:: .:|.|||.|||.|:|:.|.|...|
Mouse   404 PEKFDPSHFLD---------------------ERGKFKKS-DYFFPFSTGKRICVGEGLARAELF 446

  Fly   497 LVVVNVMQRYNISSHNPSTIKISPESLALPADCFPLVLTP 536
            |.:..::|.:|:.|               |.|...|..||
Mouse   447 LFLTTILQNFNLKS---------------PVDLKDLDTTP 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	132/513 (26%)
Cyp2c65	NP_082467.2	p450	30..487	CDD:278495	132/514 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920