DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spo and Cyp2c55

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_082365.1	Gene:	Cyp2c55 / 72082	MGIID:	1919332	Length:	490	Species:	Mus musculus

Alignment Length:	491	Identity:	137/491 - (27%)
Similarity:	226/491 - (46%)	Gaps:	97/491 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PGPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKV 120
            |||.|:|||||:..:|....|  ..|...::.||.:::|.||....:||:..|.::|.|:..|:.
Mouse    31 PGPTPFPIIGNILQIDIKNIS--KSFNYFSKVYGPVFTLYFGSKPTVVVHGYEAVKEALDDLGEE 93

  Fly   121 MSGRPDFIRYHKLFGGERSNSLAL-----CDWSQLQQ------KRRNLARRHCSPR---EFSCFY 171
            .|||..|..:.::     :|.|.:     ..|.:|::      :...:.:|....|   |.||.
Mouse    94 FSGRGSFQIFERI-----NNDLGVIFSNGTKWKELRRFSIMTLRSFGMGKRSIEDRIQEEASCL- 152

  Fly   172 MKMSQIGCEEMEHWNRELGNQLVPGEPINIKPLILKACANMFSQYMCSL----RFDYDDVDFQQI 232
                   .||:...|..|           ..|..:.:||.  |..:||:    ||||.|..|..:
Mouse   153 -------VEELRKANGSL-----------CDPTFILSCAP--SNVICSVIFHNRFDYKDEKFLNL 197

  Fly   233 VQYFDEIFWEINQGHPLDFLPWL-----YPFYQRHL----NKIINWSSTIRGFIMERIIRHRELS 288
            ::..:|.|..:|.       ||:     .|....:|    ||:|...:.|:.:|:.|:..|:| :
Mouse   198 MERLNENFKILNS-------PWMQVYNALPTLINYLPGSHNKVIKNFTEIKSYILGRVKEHQE-T 254

  Fly   289 VDLDEPDRDFTDALLKSLLEDK-----DVSRNTIIFMLED-FIGGHSAVGNLVMLVLAYIAKNVD 347
            :|:|.| |||.|..|..:.::|     :.:..:::..:.| |:.|.......:...|..:.|:.:
Mouse   255 LDMDNP-RDFIDCFLIKMEQEKHNPHSEFTIESLMATVTDIFVAGTETTNITLRYGLLLLLKHTE 318

  Fly   348 IGRRIQEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYSS--SPIVPHVATEDTVISGYGVT 410
            :..::|.|||.:| ..:||..:.|...||||.|.:.|:.||..  ...|||.||.:.....|.:.
Mouse   319 VTAKVQAEIDHVI-GRHRSPCMQDRTRMPYTDAMVHEIQRYIDLIPNNVPHAATCNVRFRSYFIP 382

  Fly   411 KGT-IVFINNYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPH 474
            ||| :|.....||:..::| .||:.|:|..||:.:     .|.|.||                 :
Mouse   383 KGTELVTSLTSVLHDDKEF-PNPEVFDPGHFLDEN-----GNFKKSD-----------------Y 424

  Fly   475 FLPFSIGKRTCIGQNLVRGFGFLVVVNVMQRYNISS 510
            |:|||||||.|:|:.|.|...||::..::|.:|:.|
Mouse   425 FMPFSIGKRMCVGEALARTELFLILTTILQNFNLKS 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	137/491 (28%)
Cyp2c55	NP_082365.1	p450	30..485	CDD:278495	137/491 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920