DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and CYP3A43

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	566	Identity:	122/566 - (21%)
Similarity:	217/566 - (38%)	Gaps:	134/566 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VLATSYICI-IYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIG-------NLHLLDR 72
            ::|||.:.: |||..               :|..::| ...|||.|.|.:|       .|...||
Human    14 LVATSLVLLYIYGTH---------------SHKLFKK-LGIPGPTPLPFLGTILFYLRGLWNFDR 62

  Fly    73 YRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQ------NGKVMSGRPDFIRYH 131
                      ...::||:::.|..|....||:.:.::|:.||.:      ..::..|...|::..
Human    63 ----------ECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSA 117

  Fly   132 KLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQI--GCEEMEHWNRELGNQLV 194
            ..|..:.       :|.::        |...||...|..:.:|..|  .|.:|  ..|.|..:..
Human   118 LSFAEDE-------EWKRI--------RTLLSPAFTSVKFKEMVPIISQCGDM--LVRSLRQEAE 165

  Fly   195 PGEPINIKPLILKACANMFSQYMCSL------RFDYDDVDFQQIVQYFDEIFWEINQGHPLDFL- 252
            ..:.||:|        :.|..|...:      ..:.|.::..|     |.....:.:...||||
Human   166 NSKSINLK--------DFFGAYTMDVITGTLFGVNLDSLNNPQ-----DPFLKNMKKLLKLDFLD 217

  Fly   253 ---------PWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDR-DFTDALLKS-- 305
                     |:|.|.::. || |..:...:..|:...|.|.:|..:...:..| ||...::.|
Human   218 PFLLLISLFPFLTPVFEA-LN-IGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQN 280

  Fly   306 --------LLEDKDVSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEE 362
                    .|.|.::...:||.:    ...:......:..::..:|.:.|:.:::||||||::
Human   281 SKETKSHKALSDLELVAQSIIII----FAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-- 339

  Fly   363 ENRSINLLD-MNAMPYTMATIFEVLRYSSSPI---VPHVATEDTVISGYGVTKGTIVFINNYVLN 423
            .|::....| :..|.|....:.|.||.  .|:   |..|..:|..|:|..:.||..|.:..|.|:
Human   340 PNKAPVTYDALVQMEYLDMVVNETLRL--FPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALH 402

  Fly   424 TSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQ 488
            ...|:|..|::|.|         :|..:.|..||        :.|.|    ::||..|.|.|||.
Human   403 HDPKYWTEPEKFCP---------ESRFSKKNKDS--------IDLYR----YIPFGAGPRNCIGM 446

  Fly   489 NLVRGFGFLVVVNVMQRYNISSHNPSTIKISPESLALPADCFPLVL 534
            ........|.|:..:|.::......:.|.:..::|.:.....|:||
Human   447 RFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVL 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	114/525 (22%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	114/525 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000