DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spo and cyp2aa1

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001020728.2	Gene:	cyp2aa1 / 572000	ZFINID:	ZDB-GENE-070424-33	Length:	498	Species:	Danio rerio

Alignment Length:	540	Identity:	136/540 - (25%)
Similarity:	237/540 - (43%)	Gaps:	107/540 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLAALIYTILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIG 65
            ||..|:...||   ||..|.::.:|:.|...:.:          .|:...::  .|||.|.|.:|
Zfish     1 MLVGLVKLDLA---SVGLTLFLGLIFLVLFEIFR----------IHSYKGRF--PPGPTPLPFVG 50

  Fly    66 NL-HLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIR 129
            || |.|    .||.. |.....|||::.::.||....:::|.::|.:|...|:  |.||||
Zfish    51 NLPHFL----KSPME-FIRFMPQYGEMTTIFFGRKPVIMLNTIQLAKEAYVQD--VFSGRP---- 104

  Fly   130 YHKLFGGERSNSLALCDW-------------SQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEE 181
                       ::.|.||             :..:|:||           |:...::...:|.:.
Zfish   105 -----------AIPLFDWITNGLGIVMVTFNNSWRQQRR-----------FALHTLRNFGLGKKT 147

  Fly   182 ME----HWNRELGNQLVPGEPINIKPLILKACANMFSQYMCSL----RFDYDDVDFQQIVQYFDE 238
            :|    ..:|.|..:::..|..::.|  ..|..|..|..:||:    ||:||:..|:.:::..:|
Zfish   148 VEDRVLEESRYLIAEMLKEEGKSMNP--QHALQNAISNIICSIVFGDRFEYDNKRFEYLLKTLNE 210

  Fly   239 IFWEINQ--GHPLDFLPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDA 301
            .......  |...:.:|::..|...| .||...:..:.|||.:....||: ::|.|.| |||.||
Zfish   211 NIMLAGSAAGQIFNLVPFIKHFPGPH-QKIKQNADELLGFIRDEAKEHRQ-TLDPDSP-RDFIDA 272

  Fly   302 LLKSLLEDKDV------SRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAII 360
            .|..:.:.|..      ..|.::...:.|:.|.......:...|..:.:|.|:..|..|||..::
Zfish   273 YLLEIEKQKSSKDSTFHEENLVVSASDLFLAGTDTTETTIRWGLINLIQNPDVQERCHEEIVRVL 337

  Fly   361 EEENRSINLLDMNAMPYTMATIFEVLRYSS-SPIVPHVATEDTVISGYGVTKGTIVFINNYVLNT 424
            ..: |..::.|.:.:|||:||::|:.|.:: :|.|.|.....|.:.||.:.:|||:..|...:.:
Zfish   338 GYD-RLPSMDDRDKLPYTLATVYEIQRCANIAPNVMHQTILPTKLHGYNIPQGTIILTNLAAIFS 401

  Fly   425 SEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQN 489
            :::.|.:|..|||..||:.:...|...|                      |:|||:|.|.|:|:.
Zfish   402 NKEHWKHPDAFNPENFLDENGHFSKPES----------------------FIPFSLGPRVCLGET 444

  Fly   490 LVRGFGFLVVVNVMQRYNIS 509
            |.|...||.:..::||...|
Zfish   445 LARTELFLFITALLQRIRFS 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	125/485 (26%)
cyp2aa1	NP_001020728.2	p450	40..487	CDD:278495	125/486 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010