DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2d22

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001156944.1	Gene:	Cyp2d22 / 56448	MGIID:	1929474	Length:	500	Species:	Mus musculus

Alignment Length:	514	Identity:	142/514 - (27%)
Similarity:	231/514 - (44%)	Gaps:	80/514 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QKYT--QAPGPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIRE 112
            |::|  ..|||.|||::|||..:| :::.| |||..|..:|||::||.......:|:|.|..:||
Mouse    30 QRWTAHYPPGPMPWPVLGNLLHMD-FQNMP-AGFQKLRGRYGDLFSLQLASESVVVLNGLTALRE 92

  Fly   113 VLNQNGKVMSGRPDFIRYHKLFG-GERSNSLALCDWSQL-QQKRRNLARRHCSPREFSCFYMKMS 175
            .|.::.:..:.||. :.::.|.| |.||..:.|..:... :|:||           ||...|...
Mouse    93 ALVKHSEDTADRPP-LHFNDLLGFGPRSQGIVLARYGPAWRQQRR-----------FSVSTMHHF 145

  Fly   176 QIGCEEMEHWNRELGNQLV------PGEPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQ 234
            .:|.:.:|.|..|....|.      .|.|.:...|:.||..|:.:..:.:.||:|||..|.:::.
Mouse   146 GLGKKSLEQWVTEEARCLCAAFADHTGHPFSPNTLLDKAVCNVIASLLYACRFEYDDPRFIRLLG 210

  Fly   235 YFDEIFWEINQGHPLDFLPW---LYPFYQRHLNKIINWSSTIRGFI--MERIIRHRELSVDLDEP 294
            ...|...|     ...|||.   ::|...|....:.......|.|:  ::.::...:.:.|..:|
Mouse   211 LLKETLKE-----EAGFLPMFLNVFPMLLRIPGLVGKVFPGKRAFVTMLDELLAEHKTTWDPTQP 270

  Fly   295 DRDFTDALLKSLLEDK--------DVSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRR 351
            .||.|||.|..:.:.|        |.:..|::..|  |..|.......:...|..:..:.|:.||
Mouse   271 PRDLTDAFLAEVEKAKGNPESSFNDENLRTVVGDL--FSAGMVTTSTTLSWALMLMILHPDVQRR 333

  Fly   352 IQEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYSS-SPI-VPHVATEDTVISGYGVTKGTI 414
            :|:|||.:|.:. :...:.|...||||.|.|.||.|::. .|: |||..:.|..:.|:.:.|||.
Mouse   334 VQQEIDEVIGQV-QCPEMADQARMPYTNAVIHEVQRFADILPLGVPHKTSRDIELQGFLIPKGTT 397

  Fly   415 VFINNYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFS 479
            :..|.......|..|..|..|:|..||:         ::|.....|:             |:|||
Mouse   398 LITNLSSALKDETVWEKPLCFHPEHFLD---------AQGHFVKPEA-------------FMPFS 440

  Fly   480 IGKRTCIGQNLVRGFGFLVVVNVMQRYNISSHNPSTIKISPESLALPAD--CFPLVLTP 536
            .|:|:|:|:.|.|...||....::||::||         .|:....|:|  .|..:.||
Mouse   441 AGRRSCLGEPLARMELFLFFTCLLQRFSIS---------VPDGQPQPSDHGVFRALTTP 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	140/506 (28%)
Cyp2d22	NP_001156944.1	p450	37..496	CDD:278495	140/507 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920