DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spo and Cyp2c67

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001019890.1	Gene:	Cyp2c67 / 545288	MGIID:	3612288	Length:	491	Species:	Mus musculus

Alignment Length:	493	Identity:	139/493 - (28%)
Similarity:	225/493 - (45%)	Gaps:	78/493 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PGPRPWPIIGNLHLLDRYRDSPFAG--FTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNG 118
            |||.|.|||||.||:| .:|   .|  .|..::.||.:::|.||....:|::..|.::|....:|
Mouse    31 PGPTPLPIIGNYHLID-MKD---IGQCLTNFSKTYGPVFTLYFGSQPIVVLHGYEAMKEAFIDHG 91

  Fly   119 KVMSGRPDFIRYHKLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEME 183
            :..|||..|..:.|:..|:.........|.              :.|.|:...::...:|...:|
Mouse    92 EEFSGRGRFPFFDKVTKGKGIGFSHGNVWK--------------ATRVFTINTLRNLGMGKRTIE 142

  Fly   184 HWNRE----LGNQLVPGEPINIKPLILKACA--NMFSQYMCSLRFDYDDVDFQQIVQYFDEIF-- 240
            :..:|    |..:|.....:...|..:..||  |:....:...||||.|.||..::...:|..
Mouse   143 NKVQEEAQWLMKELKKTNGLPCDPQFIIGCAPCNVICSIVFQNRFDYKDKDFLSLIGKVNECTEI 207

  Fly   241 -----WEINQGHP--LDFLPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDF 298
                 .:|....|  :|:.|      .|| ||.....:.|:.:::|:|..|.| |:|:..| |||
Mouse   208 LSSPGCQIFNAVPILIDYCP------GRH-NKFFKNHTWIKSYLLEKIKEHEE-SLDVTNP-RDF 263

  Fly   299 TDALLKSLLEDKDVSR-----NTIIFMLEDFI-GGHSAVGNLVMLVLAYIAKNVDIGRRIQEEID 357
            .|..|....::|.:..     ..:..::.|.: ||..::.:.:...|..:.|:..|..::|||||
Mouse   264 IDYFLIQRCQEKGIEHMEYTIEHLATLVTDLVFGGTESLSSTMRFALLLLMKHTHITAKVQEEID 328

  Fly   358 AIIEEENRSINLLDMNAMPYTMATIFEVLRY-SSSPI-VPHVATEDTVISGYGVTKGTIVFIN-N 419
            .:| ..:||..:.|.|.||||.|.:.||.|| ...|| :.|..|.||....|.:.|||.|..: .
Mouse   329 NVI-GRHRSPCMQDRNHMPYTNAMVHEVQRYVDLGPISLVHEVTCDTKFRNYFIPKGTQVMTSLT 392

  Fly   420 YVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRT 484
            .||:.|.:| .||:.|:|..||:.:     .|.|.||                 :|:|||.|||.
Mouse   393 SVLHDSTEF-PNPEVFDPGHFLDDN-----GNFKKSD-----------------YFVPFSAGKRI 434

  Fly   485 CIGQNLVRGFGFLVVVNVMQRYNISS-HNPSTIKISPE 521
            |:|::|.|...||.:..::|.:.:.. .:|..|.::|:
Mouse   435 CVGESLARMELFLFLTTILQNFKLKPLVDPKDIDMTPK 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	139/493 (28%)
Cyp2c67	NP_001019890.1	p450	30..487	CDD:278495	139/493 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920