DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2f4

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_062176.1	Gene:	Cyp2f4 / 54246	RGDID:	2476	Length:	491	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	142/532 - (26%)
Similarity:	238/532 - (44%)	Gaps:	90/532 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYGDI 91
            ||...:|..:....|..:...::.|....|||:|.||:|||..| |.:|. ....|.|::.||.:
  Rat     3 GVSTAILLLLLAVISLSLTFTSWGKGQLPPGPKPLPILGNLLQL-RSQDL-LTSLTKLSKDYGSV 65

  Fly    92 YSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKLFGGERSNSLALCD---WSQLQQK 153
            :::..|..|.:|::..:.::|.|...|:..|||..   |...|...:.|.:|..|   |..|
  Rat    66 FTVYLGPRRVIVLSGYQTVKEALVDKGEEFSGRGS---YPIFFNFTKGNGIAFSDGERWKIL--- 124

  Fly   154 RRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLV------PGEPINIKPLILKACANM 212
                       |.||...::...:|...:|....|.|:.|:      .|:|.:...::.::.:|:
  Rat   125 -----------RRFSVQILRNFGMGKRSIEERILEEGSFLLDVLRKTEGKPFDPVFILSRSVSNI 178

  Fly   213 FSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHPLDFLPW--LYPFYQRHLNKIINW-----S 270
            ....:...||||||.....|:.:       ||....:...||  :|..:.    .:::|     .
  Rat   179 ICSVIFGSRFDYDDERLLTIIHF-------INDNFQIMSSPWGEMYNIFP----SLLDWVPGPHR 232

  Fly   271 STIRGF-----IMERIIRHRELSVDLDEPDRDFTDALLKSLLEDKD-----VSRNTIIFMLEDFI 325
            ...|.|     ::.|.:|..:.|:|.:.| |||.|..|..::::|.     .:.:|::....:.:
  Rat   233 RVFRNFGGMKDLIARSVREHQDSLDPNSP-RDFIDCFLTKMVQEKQDPLSHFNMDTLLMTTHNLL 296

  Fly   326 -GGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYS 389
             ||...||..:......:.|...:..|:|||||.:: ..:|...|.|..:||||.|.|.||.|::
  Rat   297 FGGTETVGTTLRHAFLILMKYPKVQARVQEEIDCVV-GRSRMPTLEDRASMPYTDAVIHEVQRFA 360

  Fly   390 S-SPI-VPHVATEDTVISGYGVTKGT-IVFINNYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKN 451
            . .|: :||....||...|:.:.||| ::.:.|.|...|::| ..|:||||..||:.:  ||.|.
  Rat   361 DVIPMNLPHRVIRDTPFRGFLIPKGTDVITLLNTVHYDSDQF-KTPQEFNPEHFLDAN--QSFKK 422

  Fly   452 SKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVVVNVMQRYNISSH---NP 513
            |                    |.|:|||.|:|.|:|:.|.|...|:.:.:::|  |.:.|   .|
  Rat   423 S--------------------PAFMPFSAGRRLCLGEPLARMELFIYLTSILQ--NFTLHPLVEP 465

  Fly   514 STIKISPESLAL 525
            ..|.::|.|..|
  Rat   466 EDIDLTPLSSGL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	137/503 (27%)
Cyp2f4	NP_062176.1	p450	31..488	CDD:278495	137/504 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920