DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp304a1

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_731751.1	Gene:	Cyp304a1 / 41586	FlyBaseID:	FBgn0038095	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	139/571 - (24%)
Similarity:	222/571 - (38%)	Gaps:	132/571 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILAILLSVLATSYICII--YGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGN--LHL 69
            |...||::.|..::|:.  |.|.|....|                    |||...|:.|:  ..|
  Fly     2 ITETLLTICAAVFLCLSYRYAVGRPSGFP--------------------PGPPKIPLFGSYLFML 46

  Fly    70 LDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKLF 134
            :..::....|..|.......||..|..|.....||::.:.:||:|  |.:|..|||.........
  Fly    47 IINFKYLHKAALTLSRWYKSDIIGLHVGPFPVAVVHSADGVREIL--NNQVFDGRPQLFVAAMRD 109

  Fly   135 GGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNREL----GNQLVP 195
            .|:....:...|....:::||.:.|   ..|:|. |..:..|:.....|..|..|    .....|
  Fly   110 PGQDVRGIFFQDGPLWKEQRRFILR---YLRDFG-FGRRFDQLELVIQEQLNDMLDLIRNGPKYP 170

  Fly   196 GEPINIK--------PLI---LKACANMFSQY--------------MCSLRFDYDDVDFQQIVQY 235
            .|...:|        ||:   ..|.|:.:..|              :|.:     .:.||:...
  Fly   171 HEHEMVKSGGYRVLLPLLFNPFSANAHFYIVYNECLSREEMGKLVKLCQM-----GIQFQRNAD- 229

  Fly   236 FDEIFWEINQGHPLDFLPWLYPFYQRHL-------NKIINWSSTIRGFIMERIIRHRELSVDLDE 293
                    :.|..|..:||:     ||:       ||:...:..:|.|..:.:.::      ||.
  Fly   230 --------DYGKMLSIIPWI-----RHIWPEWSGYNKLNESNLFVRQFFADFVDKY------LDS 275

  Fly   294 ----PDRDFTDALLKSLLEDK--DVSRNTIIFMLEDF-IGGHSAVGNLVMLVLAYIAKNVDIGRR 351
                .:|:|.|..:..:....  ..:|:.:|..|.|| ....:|:|..:.|::.|:.....:.||
  Fly   276 YEEGVERNFMDVYIAEMRRGPGYGFNRDQLIMGLVDFSFPAFTAIGVQLSLLVQYLMLYPAVLRR 340

  Fly   352 IQEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYSS--SPIVPHVATEDTVISGYGVTKGTI 414
            :|.|||.:: ...|..||.|...:|:|.|||.|.||..:  ...|||.|.|||.:.||.:.|.||
  Fly   341 VQNEIDEVV-GCGRLPNLEDRKNLPFTEATIREGLRIETLVPSDVPHKALEDTELLGYRIPKDTI 404

  Fly   415 VFINNYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFS 479
            |..:.|..::..:.|.:|::|.|.|||:.                   :.||.||.::.  |||.
  Fly   405 VVPSLYAFHSDARIWSDPEQFRPERFLDA-------------------DGKLCLKLDVS--LPFG 448

  Fly   480 IGKRTCIGQNLVRGFGFLVVVNVMQRYNI----------SSHNPSTIKISP 520
            .|||.|.|:...|...|||...:.|.::.          .|.|.:.:.|||
  Fly   449 AGKRLCAGETFARNMLFLVTATMCQHFDFVLGPNDRLPDLSQNLNGLIISP 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	130/522 (25%)
Cyp304a1	NP_731751.1	p450	30..504	CDD:278495	131/543 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457261
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24303
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
	3	3.030