DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp18a1

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_523403.2	Gene:	Cyp18a1 / 32858	FlyBaseID:	FBgn0010383	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	588	Identity:	145/588 - (24%)
Similarity:	253/588 - (43%)	Gaps:	125/588 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VLATSYICIIYGVKRRVLQPVKTKNSTEINH-------------------NAYQKYTQAPGPRPW 61
            :||.||:.      :.||:.::.:...:..|                   ..|::..:.| |.||
  Fly     1 MLADSYLI------KFVLRQLQVQQDGDAQHLLMVFLGLLALVTLLQWLVRNYRELRKLP-PGPW 58

  Fly    62 --PIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGR 124
              |:||.|..:...:.:   .|..||:|||.::|...|....:|:::.::|||...:  :..:||
  Fly    59 GLPVIGYLLFMGSEKHT---RFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRR--EEFTGR 118

  Fly   125 PDFIRYHKLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYM--KMSQIGCEEMEHWNR 187
            ||......|.|....||.... |   :.:||.|   |...|:|...||  ...|:....|...:.
  Fly   119 PDTPFMQTLNGYGIINSTGKL-W---KDQRRFL---HDKLRQFGMTYMGNGKQQMQKRIMTEVHE 176

  Fly   188 ELGN-QLVPGEPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDE---IFWEINQGHP 248
            .:|: ....|:|:::.|:|..|.:|:....|.|.||..||..|::.....:|   :|.||   |.
  Fly   177 FIGHLHASDGQPVDMSPVISVAVSNVICSLMMSTRFSIDDPKFRRFNFLIEEGMRLFGEI---HT 238

  Fly   249 LDFLPWL--YPFYQRHLNKIINWSSTIRGFIMERIIRH---------RELSVD-----LDEPDRD 297
            :|::|.:  :|......|||....:.::.|..:.|..|         |:| ||     :::...:
  Fly   239 VDYIPTMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKRSFDPNNIRDL-VDFYLCEIEKAKAE 302

  Fly   298 FTDALLKSLLEDKDVSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEE 362
            .|||   .|.:.|:.....:..:::.|..|...:...::.:..::.:|....||:|:|:|.:: .
  Fly   303 GTDA---ELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVV-G 363

  Fly   363 ENRSINLLDMNAMPYTMATIFEVLRYSSSPIVP----HVATEDTVISGYGVTKGT--IVFINNYV 421
            .:|...:.|:..:|.|.:||.|.:|.||  |||    |..|.|..::||.:..|:  |..||:
  Fly   364 RHRLPTIEDLQYLPITESTILESMRRSS--IVPLATTHSPTRDVELNGYTIPAGSHVIPLINS-- 424

  Fly   422 LNTSEKFWVNPKEFNPLRFLE-PSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTC 485
            ::.....|..|:||.|.||:: ..|.:.|:                       :|:||.:|:|.|
  Fly   425 VHMDPNLWEKPEEFRPSRFIDTEGKVRKPE-----------------------YFIPFGVGRRMC 466

  Fly   486 IGQNLVRGFGFLVVVNVMQRYNISSHNPSTIKISPESLALPA-----------DCFPLVLTPREK 539
            :|..|.|...||...:.|..::|:         .||...||:           :.|.:.| .|..
  Fly   467 LGDVLARMELFLFFASFMHCFDIA---------LPEGQPLPSLKGNVGATITPESFKVCL-KRRP 521

  Fly   540 IGP 542
            :||
  Fly   522 LGP 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	135/525 (26%)
Cyp18a1	NP_523403.2	p450	54..517	CDD:278495	133/519 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457265
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
	3	2.840