DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spo and Cyp2b21

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_942028.1	Gene:	Cyp2b21 / 292728	RGDID:	735174	Length:	494	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	151/532 - (28%)
Similarity:	230/532 - (43%)	Gaps:	126/532 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PGPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKV 120
            |||.|.|::||:..:|  |......|..|..:|||:.::..|....:::...|.|||.|..:.:.
  Rat    32 PGPCPLPLLGNVLQMD--RRGLLKSFIQLRDKYGDVVTVHLGPRPIVMLYGTETIREALVDHAEA 94

  Fly   121 MSGR-------PDFIRYHKLF-GGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQI 177
            .|||       |....|..:| .|||        |..|              |.||...|:...:
  Rat    95 FSGRGTVAVVQPIIQDYGMIFANGER--------WKIL--------------RRFSLATMRDFGM 137

  Fly   178 GCEEMEHWNRELGNQLV------PGEPINIKPLILKAC--ANMFSQYMCSLRFDYDDVDFQQIVQ 234
            |...:|...:|....||      .|.|::  |.....|  ||:....:...||||.|..|..::.
  Rat   138 GKRSVEERIKEEAQCLVEELKKYKGAPLD--PTFHLQCITANIICSIVFGERFDYTDHQFLHLLD 200

  Fly   235 YFDEIF----------WEINQGHPLDFLPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSV 289
            .|.||.          :|:..|    ||.: :|...||::|.|   ..|..||...:.:|| .::
  Rat   201 LFYEILSLVSSFSSQVFELFTG----FLKY-FPGTHRHISKNI---EEILNFIGHCVEKHR-ATL 256

  Fly   290 DLDEPDRDFTDALLKSLLEDK------DVSRNTIIFMLEDFIGGHSA------VGNLVMLVLAYI 342
            |...| |||.|..|..:.::|      ...:|.::.:|..|..|...      .|.|:||...::
  Rat   257 DPSTP-RDFIDTYLLRMEKEKLNHHTEFHHQNLMMSVLSLFFAGTETSSTTLRYGFLLMLKYPHV 320

  Fly   343 AKNVDIGRRIQEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYSS-SPI-VPHVATEDTVIS 405
            |:      ::|:|||.:| ..:|...|.|...||||.|.|.|:.|:|. .|| :||..|:||:..
  Rat   321 AE------KVQKEIDQVI-GSHRVPTLDDRIKMPYTDAVIHEIQRFSDLVPIGLPHRVTKDTLFR 378

  Fly   406 GYGVTKGTIVF-INNYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLK 469
            ||.:.|...|: |.:..|: ..:::.:|..|||..||:         :.|:            ||
  Rat   379 GYLLPKNIEVYPILSSALH-DPQYFEHPDTFNPEHFLD---------ANGA------------LK 421

  Fly   470 RNIPHFLPFSIGKRTCIGQNLVRGFGFLVVVNVMQRYNISSHNPSTIKISPESLALPADCFPLVL 534
            :| ..|||||.|||.|:|:.:.|...||....::|.:::||      .:||:.:.         |
  Rat   422 KN-EAFLPFSTGKRVCLGEGIARNELFLFFTTILQNFSVSS------PVSPKDID---------L 470

  Fly   535 TPRE----KIGP 542
            ||:|    ||.|
  Rat   471 TPKESGFAKIPP 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	148/528 (28%)
Cyp2b21	NP_942028.1	p450	42..488	CDD:278495	145/522 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010