DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2d5

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_775426.1	Gene:	Cyp2d5 / 286963	RGDID:	628630	Length:	504	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	139/566 - (24%)
Similarity:	246/566 - (43%)	Gaps:	109/566 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IYTILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQ--APGPRPWPIIGNLH 68
            |:|::.|||                           .::.|. :|::|.  .|||.|||::|||.
  Rat    14 IFTVIFILL---------------------------VDLMHR-HQRWTSRYPPGPVPWPVLGNLL 50

  Fly    69 LLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKL 133
            .:|. .:.|::.: .|..:|||::||..|....::||.|:.::|||..:|:..:.||....:..|
  Rat    51 QVDP-SNMPYSMY-KLQHRYGDVFSLQMGWKPMVIVNRLKAVQEVLVTHGEDTADRPPVPIFKCL 113

  Fly   134 FGGERSNSLALCDWS-QLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHW-NRELGN----- 191
            ....||..:....:. :.:::||           ||...::...:|.:.:|.| .:|.|:
  Rat   114 GVKPRSQGVVFASYGPEWREQRR-----------FSVSTLRTFGMGKKSLEEWVTKEAGHLCDAF 167

  Fly   192 QLVPGEPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHPLDFLPWLY 256
            ....|..||.|.::.||..|:.:..:.:.||:|:|....:::...:|...|::     .|:|.:.
  Rat   168 TAQNGRSINPKAMLNKALCNVIASLIFARRFEYEDPYLIRMLTLVEESLIEVS-----GFIPEVL 227

  Fly   257 PFYQRHL------NKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALL------KSLLED 309
            ..:...|      :|:.....|...| ::.::.....:.|..:|.|:.|||.|      |...|.
  Rat   228 NTFPALLRIPGLADKVFQGQKTFMAF-LDNLLAENRTTWDPAQPPRNLTDAFLAEVEKAKGNPES 291

  Fly   310 KDVSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDMNA 374
            .....|..:.:::.|..|.......:...|..:....|:.||:|:|||.:|.:. |...:.|...
  Rat   292 SFNDENLRMVVVDLFTAGMVTTATTLTWALLLMILYPDVQRRVQQEIDEVIGQV-RCPEMTDQAH 355

  Fly   375 MPYTMATIFEVLRYSS-SPI-VPHVATEDTVISGYGVTKGTIVFINNYVLNTSEKFWVNPKEFNP 437
            ||||.|.|.||.|:.. :|: :|.:.:.|..:..:.:.|||.:.||...:...|..|..|..|:|
  Rat   356 MPYTNAVIHEVQRFGDIAPLNLPRITSCDIEVQDFVIPKGTTLIINLSSVLKDETVWEKPLRFHP 420

  Fly   438 LRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVVVNV 502
            ..||:         ::|:....|:             |:|||.|:|.|:|:.|.|...||....:
  Rat   421 EHFLD---------AQGNFVKHEA-------------FMPFSAGRRACLGEPLARMELFLFFTCL 463

  Fly   503 MQRYNIS----SHNPST-----IKISPESLALPADCFPLVLTPREK 539
            :|.::.|    ...|||     |.::|    ||   :.|....||:
  Rat   464 LQHFSFSVPAGQPRPSTLGNFAISVAP----LP---YQLCAAVREQ 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	131/514 (25%)
Cyp2d5	NP_775426.1	p450	37..496	CDD:278495	128/507 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920