DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2d1

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_695225.1	Gene:	Cyp2d1 / 266684	RGDID:	708427	Length:	504	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	136/535 - (25%)
Similarity:	238/535 - (44%)	Gaps:	93/535 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IYTILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHLL 70
            |:|::.|||..|          :.||              |....:|  .|||.|||::|||..:
  Rat    14 IFTVIFILLVDL----------MHRR--------------HRWTSRY--PPGPVPWPVLGNLLQV 52

  Fly    71 DRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKLFG 135
            | ..:.|::.: .|..:|||::||..|....::||.|:.::|||..:|:..:.||....:..|..
  Rat    53 D-LSNMPYSLY-KLQHRYGDVFSLQKGWKPMVIVNRLKAVQEVLVTHGEDTADRPPVPIFKCLGV 115

  Fly   136 GERSNSLALCDWS-QLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHW-NRELGN-----QL 193
            ..||..:.|..:. :.:::||           ||...::...:|.:.:|.| .:|.|:     ..
  Rat   116 KPRSQGVILASYGPEWREQRR-----------FSVSTLRTFGMGKKSLEEWVTKEAGHLCDAFTA 169

  Fly   194 VPGEPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHPLDFLPWLYPF 258
            ..|:.||.|.::.||..|:.:..:.:.||:|:|....::|:..:|...|::     .|:|.:...
  Rat   170 QAGQSINPKAMLNKALCNVIASLIFARRFEYEDPYLIRMVKLVEESLTEVS-----GFIPEVLNT 229

  Fly   259 YQRHL------NKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALL------KSLLEDKD 311
            :...|      :|:.....|... :::.::.....:.|..:|.|:.|||.|      |...|...
  Rat   230 FPALLRIPGLADKVFQGQKTFMA-LLDNLLAENRTTWDPAQPPRNLTDAFLAEVEKAKGNPESSF 293

  Fly   312 VSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDMNAMP 376
            ...|..:.:::.|..|.......:...|..:....|:.||:|:|||.:|.:. |...:.|...||
  Rat   294 NDENLRMVVVDLFTAGMVTTATTLTWALLLMILYPDVQRRVQQEIDEVIGQV-RCPEMTDQAHMP 357

  Fly   377 YTMATIFEVLRYSS-SPI-VPHVATEDTVISGYGVTKGTIVFINNYVLNTSEKFWVNPKEFNPLR 439
            ||.|.|.||.|:.. :|: :|.:.:.|..:..:.:.|||.:.||...:...|..|..|..|:|..
  Rat   358 YTNAVIHEVQRFGDIAPLNLPRITSCDIEVQDFVIPKGTTLIINLSSVLKDETVWEKPHRFHPEH 422

  Fly   440 FLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVVVNVMQ 504
            ||:         ::|:....|:             |:|||.|:|.|:|:.|.|...||....::|
  Rat   423 FLD---------AQGNFVKHEA-------------FMPFSAGRRACLGEPLARMELFLFFTCLLQ 465

  Fly   505 RYNIS----SHNPST 515
            |::.|    ...|||
  Rat   466 RFSFSVPVGQPRPST 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	126/485 (26%)
Cyp2d1	NP_695225.1	p450	37..496	CDD:278495	126/486 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920