DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2d3

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_775116.1	Gene:	Cyp2d3 / 24303	RGDID:	2472	Length:	500	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	136/559 - (24%)
Similarity:	243/559 - (43%)	Gaps:	110/559 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IYTILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQ--APGPRPWPIIGNLH 68
            |:|::.|||                           .::.|.. |::|.  .|||.|||::|||.
  Rat    14 IFTVIFILL---------------------------VDLMHRR-QRWTSRYPPGPVPWPVLGNLL 50

  Fly    69 LLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKL 133
            .:| ..:.|::.: .|..:|||::||..|....:|:|.|:.::|:|...|:..:.||:...:..:
  Rat    51 QVD-LCNMPYSMY-KLQNRYGDVFSLQMGWKPVVVINGLKAVQELLVTCGEDTADRPEMPIFQHI 113

  Fly   134 FGGERSNSLALC----DWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLV 194
            ..|.::..:.|.    :|.:              .|.||...::...:|.:.:|.|..:..:.|.
  Rat   114 GYGHKAKGVVLAPYGPEWRE--------------QRRFSVSTLRNFGVGKKSLEQWVTDEASHLC 164

  Fly   195 ------PGEPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHPLDFLP 253
                  .|.|::...|:.||..|:.:..:.:.||||.|.||.::::...|     :.|......|
  Rat   165 DALTAEAGRPLDPYTLLNKAVCNVIASLIYARRFDYGDPDFIKVLKILKE-----SMGEQTGLFP 224

  Fly   254 W---LYPFYQR---HLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLKSLLEDK-- 310
            .   ::|...|   ..:|:.....|....:...:..|:: :.|.|:|.||.|||.|..:.:.|
  Rat   225 EVLNMFPVLLRIPGLADKVFPGQKTFLTMVDNLVTEHKK-TWDPDQPPRDLTDAFLAEIEKAKGN 288

  Fly   311 -DVSRN--TIIFMLEDFIGGHSAVGNLVML-VLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLD 371
             :.|.|  .:..::.|..|......::.:. .|..:..:.|:..|:|:|||.:|.:. |...:.|
  Rat   289 PESSFNDANLRLVVNDLFGAGMVTTSITLTWALLLMILHPDVQCRVQQEIDEVIGQV-RHPEMAD 352

  Fly   372 MNAMPYTMATIFEVLRYSS-SPI-VPHVATEDTVISGYGVTKGTIVFINNYVLNTSEKFWVNPKE 434
            ...||:|.|.|.||.|::. .|: :||..:.|..:.|:.:.|||.:..|...:...|..|..|..
  Rat   353 QAHMPFTNAVIHEVQRFADIVPMNLPHKTSRDIEVQGFLIPKGTTLIPNLSSVLKDETVWEKPLR 417

  Fly   435 FNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVV 499
            |:|..||:         ::|:....|:             |:|||.|:|.|:|:.|.|...||..
  Rat   418 FHPEHFLD---------AQGNFVKHEA-------------FMPFSAGRRACLGEPLARMELFLFF 460

  Fly   500 VNVMQRYNISSHNPSTIKISPESLALPAD--CFPLVLTP 536
            ..::||::.|         .|.....|:|  .|..:|:|
  Rat   461 TCLLQRFSFS---------VPTGQPRPSDYGVFAFLLSP 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	128/507 (25%)
Cyp2d3	NP_775116.1	p450	37..496	CDD:278495	128/508 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920