DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2b1

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_038950984.1	Gene:	Cyp2b1 / 24300	RGDID:	2466	Length:	517	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	151/556 - (27%)
Similarity:	239/556 - (42%)	Gaps:	148/556 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PGPRPWPIIGNLHLLDR-------YRDSP-----------------FAGFTALAQQYGDIYSLTF 96
            |||||.|::|||..|||       .:..|                 .:....|.::|||::::..
  Rat    32 PGPRPLPLLGNLLQLDRGGLLNSFMQPGPPQPTDLQGVVVASTMQHLSPAVKLREKYGDVFTVHL 96

  Fly    97 GHTRCLVVNNLELIREVLNQNGKVMSGR-------PDFIRYHKLF-GGERSNSLALCDWSQLQQK 153
            |....:::...:.|:|.|....:..|||       |.|..|..:| .|||        |..|
  Rat    97 GPRPVVMLCGTDTIKEALVGQAEDFSGRGTIAVIEPIFKEYGVIFANGER--------WKAL--- 150

  Fly   154 RRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLV------PGEPINIKPLILKAC--A 210
                       |.||...|:...:|...:|...:|....||      .|.|::  |..|..|  |
  Rat   151 -----------RRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKSQGAPLD--PTFLFQCITA 202

  Fly   211 NMFSQYMCSLRFDYDDVDFQQIVQYFDEIF----------WEINQGHPLDFLPWLYPFYQRHLNK 265
            |:....:...||||.|..|.::::.|...|          :|...|. |.:.|..:....::|.:
  Rat   203 NIICSIVFGERFDYTDRQFLRLLELFYRTFSLLSSFSSQVFEFFSGF-LKYFPGAHRQISKNLQE 266

  Fly   266 IINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLKSLLEDKD------VSRNTIIFMLEDF 324
            |:::.    |.|:|   :|| .::|...| |||.|..|..:.::|.      ...|.:|.:|..|
  Rat   267 ILDYI----GHIVE---KHR-ATLDPSAP-RDFIDTYLLRMEKEKSNHHTVFHHENLMISLLSLF 322

  Fly   325 IGGHSA------VGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDMNAMPYTMATIF 383
            ..|...      .|.|:||...::|:      ::|:|||.:| ..:|...|.|.:.||||.|.|.
  Rat   323 FAGTETSSTTLRYGFLLMLKYPHVAE------KVQKEIDQVI-GSHRLPTLDDRSKMPYTDAVIH 380

  Fly   384 EVLRYSS-SPI-VPHVATEDTVISGYGVTKGTIVF-INNYVLNTSEKFWVNPKEFNPLRFLEPSK 445
            |:.|:|. .|| |||..|:||:..||.:.|.|.|: |.:..|: ..:::.:|..|||..||:
  Rat   381 EIQRFSDLVPIGVPHRVTKDTMFRGYLLPKNTEVYPILSSALH-DPQYFDHPDSFNPEHFLD--- 441

  Fly   446 EQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVVVNVMQRYNISS 510
                  :.|:            ||:: ..|:|||.|||.|:|:.:.|...||....::|.:::||
  Rat   442 ------ANGA------------LKKS-EAFMPFSTGKRICLGEGIARNELFLFFTTILQNFSVSS 487

  Fly   511 HNPSTIKISPESLALPADCFPLVLTPRE----KIGP 542
            |      ::|:.:.         |||:|    ||.|
  Rat   488 H------LAPKDID---------LTPKESGIGKIPP 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	148/552 (27%)
Cyp2b1	XP_038950984.1	CYP2B	88..512	CDD:410765	137/500 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010