DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp21a1

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_476442.2	Gene:	Cyp21a1 / 24298	RGDID:	2461	Length:	493	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	129/515 - (25%)
Similarity:	210/515 - (40%)	Gaps:	124/515 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 GNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIR 129
            |.||.|.  .:.|...| .|||:.|.||.:..|....:|:|:.:.|.|.|.|.....:|||
  Rat    38 GFLHFLQ--PNLPVYLF-GLAQKLGPIYRIRLGLQDVVVLNSNKTIEEALIQKWVDFAGRP---- 95

  Fly   130 YHKLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLV 194
              ::..|:.:..|::.|:|...:..:.|:|                               :.||
  Rat    96 --QILDGKMNFDLSMGDYSLTWKAHKKLSR-------------------------------SALV 127

  Fly   195 PGEPINIKPLI----LKACANM-------------FSQYMCS----LRF-DYDDVDF-------- 229
            .|...:::||:    .:.|..|             ||...||    |.| |..|...
  Rat   128 LGMRDSMEPLVEQLTQEFCERMRAQAGASVAIHKEFSLLTCSIISCLTFGDKQDSTLLNATHSCV 192

  Fly   230 QQIVQYFDEIFWEINQGHPLDFLPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEP 294
            :.:::.::.  |.:   ..||.:|:|..|....|.|:..:..:....:|:.:.||::..|  ...
  Rat   193 RDLLKAWNH--WSV---QILDIIPFLRFFPNPGLWKLKQFQESRDHIVMQELKRHKDSLV--AGQ 250

  Fly   295 DRDFTDALLKSLLEDKDV-------SRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRI 352
            .:|..|.:|:.:.:.:|.       .|:..:.:::.|:||.......:...:|::..:.:|.:|:
  Rat   251 WKDMIDYMLQGVEKQRDARDPGQLHERHVHMSVVDLFVGGTETTAATLSWAVAFLLHHPEIQKRL 315

  Fly   353 QEEIDAIIEEENRSINLLDMNAM--PYTMATIFEVLRYSSSPIV----PHVATEDTVISGYGVTK 411
            |||:|..:..   |..||..|.|  |..||||.||||.  .|:|    ||.||:.:.||||.:.|
  Rat   316 QEELDLKLAP---SSQLLYKNRMQLPLLMATIAEVLRL--RPVVPMALPHRATKASSISGYDIPK 375

  Fly   412 GTIVFINNYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFL 476
            .||:..|....|..|..|..|.:|.|.||||..|  ||:                     ||
  Rat   376 DTIIIPNIQGANLDEMVWELPSKFWPDRFLESGK--SPR---------------------IP--- 414

  Fly   477 PFSIGKRTCIGQNLVRGFGFLVVVNVMQRYNISSHNPSTIKISPESLALPADCFPLVLTP 536
            .|..|.|.|:|:.|.|...|:|:..::|.:.:......|:   |....||.....|::.|
  Rat   415 TFGCGARVCLGEPLARLELFVVLARLLQTFTLLPPPDGTL---PSLQPLPYTGINLLIPP 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	129/515 (25%)
Cyp21a1	NP_476442.2	p450	31..474	CDD:278495	129/515 (25%)
Cyp21a1	NP_476442.2	Steroid-binding. /evidence=ECO:0000250	337..353		9/17 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000