DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	120/573 - (20%)
Similarity:	211/573 - (36%)	Gaps:	138/573 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LIYTILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHL 69
            |:.|||.:|          .:||..               .|..::| ....||:|.|.:||:.
  Rat    14 LLATILVLL----------YLYGTS---------------THGNFKK-LGISGPKPLPFVGNIL- 51

  Fly    70 LDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKLF 134
              .||...:.......::||||:....|....|.:.:.::|:.||     |......|.. .:.|
  Rat    52 --AYRHGFWEFDRHCHKKYGDIWGFYEGRQPILAITDPDIIKTVL-----VKECYSTFTN-RRSF 108

  Fly   135 G--GERSNSLALC---DWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLV 194
            |  |....::.|.   :|.:|        |...||...|....:|..|..:..:...:.:.::..
  Rat   109 GPAGILKKAITLSEDEEWKRL--------RTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAE 165

  Fly   195 PGEPINIKPLI-------------------LKACANMFSQYMCS-LRFDYDDVDFQQIVQYFDEI 239
            .|.||.:|.:.                   |....|.|.|.:.. |:|::.|..|..::.:
  Rat   166 KGNPITMKDIFGAYSMDVITGTSFGVNVDSLNNPQNPFVQKVKKLLKFNFLDPFFLSVILF---- 226

  Fly   240 FWEINQGHPLDFLPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDR-DFTDALL 303
                         |:|.|.::..  .|..:...:..|....:.|.:|..:......| ||...::
  Rat   227 -------------PFLTPVFEAF--DITVFPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMI 276

  Fly   304 KSL----------LEDKDVSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDA 358
            .|.          |.|.::...:|.|:    ..|:....:.:...|..:|.:.|:.:::|:||||
  Rat   277 NSQSSGDKESHQGLTDVEIVAQSIFFI----FAGYETTSSALSFALYLLATHPDLQKKLQDEIDA 337

  Fly   359 IIEEENRSINLLD-MNAMPYTMATIFEVLRYSSSPI---VPHVATEDTVISGYGVTKGTIVFINN 419
            .:  .|::....| :..|.|....:.|.||.  .|:   :..|..:|..|:|..:.|||:|.:..
  Rat   338 AL--PNKAPVTYDVLVEMEYLDMVLNETLRL--FPVGGRLERVCKKDVEINGVFIPKGTVVMVPT 398

  Fly   420 YVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPH-FLPFSIGKR 483
            :.|:...|.|..|:||.|.||.:  |.|...|                     |: :|||..|.|
  Rat   399 FALHKDPKCWPEPEEFCPERFRK--KNQDSIN---------------------PYIYLPFGNGPR 440

  Fly   484 TCIGQNLVRGFGFLVVVNVMQRYN--ISSHNPSTIKISPESLALPADCFPLVL 534
            .|||.........:.:|.|:|.::  :.......:|:..:....|..  |::|
  Rat   441 NCIGMRFALMNMKIALVRVLQNFSFGLCKETQIPLKLRKKGFFQPEK--PIIL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	111/522 (21%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	110/520 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000