DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spo and CYP17A1

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_000093.1	Gene:	CYP17A1 / 1586	HGNCID:	2593	Length:	508	Species:	Homo sapiens

Alignment Length:	530	Identity:	138/530 - (26%)
Similarity:	230/530 - (43%)	Gaps:	92/530 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IYTILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPR------PWPII 64
            ::.::|:||..||     .::..|||                       .||.:      ..|::
Human     1 MWELVALLLLTLA-----YLFWPKRR-----------------------CPGAKYPKSLLSLPLV 37

  Fly    65 GNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIR 129
            |:|..|.|: ......|..|.::||.|||:..|....::|.:.:|.:|||.:.||..||||....
Human    38 GSLPFLPRH-GHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMAT 101

  Fly   130 YHKLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFY---MKMSQIGCEEMEHWNRELGN 191
            ..  ........:|..|.....|..|.||.     ..|:.|.   .|:.:|.|:|:.    .|.:
Human   102 LD--IASNNRKGIAFADSGAHWQLHRRLAM-----ATFALFKDGDQKLEKIICQEIS----TLCD 155

  Fly   192 QLVP--GEPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHPLDFLPW 254
            .|..  |:.|:|...:..|..|:.|....:..:...|.:...|..|.:.|...:::...:|.:||
Human   156 MLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPW 220

  Fly   255 LYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLKSLLE--------DKD 311
            |..|..:.|.|:.: ...||..::.:|:.:.:.....|. ..:..|.|:::.:.        |:|
Human   221 LKIFPNKTLEKLKS-HVKIRNDLLNKILENYKEKFRSDS-ITNMLDTLMQAKMNSDNGNAGPDQD 283

  Fly   312 ---VSRNTIIFMLEDFIG-GHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDM 372
               :|.|.|:..:.|..| |.....::|...||::..|..:.:::.||||..: ..:|:..:.|.
Human   284 SELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNV-GFSRTPTISDR 347

  Fly   373 NAMPYTMATIFEVLRYS--SSPIVPHVATEDTVISGYGVTKGTIVFINNYVLNTSEKFWVNPKEF 435
            |.:....|||.||||..  :..::||.|..|:.|..:.|.|||.|.||.:.|:.:||.|..|.:|
Human   348 NRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 412

  Fly   436 NPLRFLEPSKEQ--SPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLV 498
            .|.|||.|:..|  ||..|                      :|||..|.|:|||:.|.|...||:
Human   413 MPERFLNPAGTQLISPSVS----------------------YLPFGAGPRSCIGEILARQELFLI 455

  Fly   499 VVNVMQRYNI 508
            :..::||:::
Human   456 MAWLLQRFDL 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	130/480 (27%)
CYP17A1	NP_000093.1	p450	28..493	CDD:306555	128/475 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910