DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and CYP2E1

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_000764.1	Gene:	CYP2E1 / 1571	HGNCID:	2631	Length:	493	Species:	Homo sapiens

Alignment Length:	562	Identity:	144/562 - (25%)
Similarity:	247/562 - (43%)	Gaps:	109/562 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHLLDRYR 74
            |.:.:::|..:...::..:.|:|                :..:...|||.|.||||||..|: .:
Human     4 LGVTVALLVWAAFLLLVSMWRQV----------------HSSWNLPPGPFPLPIIGNLFQLE-LK 51

  Fly    75 DSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKLFGGERS 139
            :.| ..||.|||::|.:::|..|..|.:|::..:.::|.|.......|||.|...:|    ..|.
Human    52 NIP-KSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFH----AHRD 111

  Fly   140 NSLALCD---WSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEME-------HWNRELGNQLV 194
            ..:...:   |..:              |.||...::...:|.:..|       |:..| ..:..
Human   112 RGIIFNNGPTWKDI--------------RRFSLTTLRNYGMGKQGNESRIQREAHFLLE-ALRKT 161

  Fly   195 PGEPINIKPLILKACA--NMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHPLDFLPWL-- 255
            .|:|.:  |..|..||  |:.:..:....|||:|..|.:::..|:|.|      |.|. .|||
Human   162 QGQPFD--PTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENF------HLLS-TPWLQL 217

  Fly   256 ---YPFYQRHL----NKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLKSLLEDKDVS 313
               :|.:..:|    .|:|...:.::.::.||:..|.: |:|.:.| ||.||.||..:.::|..:
Human   218 YNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQ-SLDPNCP-RDLTDCLLVEMEKEKHSA 280

  Fly   314 R------NTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDM 372
            .      ...:.:.:.|..|.......:...|..:.|..:|..::.||||.:| ..:|...:.|.
Human   281 ERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI-GPSRIPAIKDR 344

  Fly   373 NAMPYTMATIFEVLRYSS--SPIVPHVATEDTVISGYGVTKGTIVFIN-NYVLNTSEKFWVNPKE 434
            ..|||..|.:.|:.|:.:  ...:||.||.||:..||.:.|||:|... :.||..:::| .:|::
Human   345 QEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF-PDPEK 408

  Fly   435 FNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVV 499
            |.|..||                     ||..:.|.: .:|.|||.|||.|.|:.|.|...||::
Human   409 FKPEHFL---------------------NENGKFKYS-DYFKPFSTGKRVCAGEGLARMELFLLL 451

  Fly   500 VNVMQRYNISS-HNPSTIKISPESLALPADCFPLVLTPREKI 540
            ..::|.:|:.. .:|..|.:||  :.:...|.|    ||.|:
Human   452 CAILQHFNLKPLVDPKDIDLSP--IHIGFGCIP----PRYKL 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	139/514 (27%)
CYP2E1	NP_000764.1	p450	33..489	CDD:365848	140/517 (27%)
CYP2E1	NP_000764.1	Substrate binding. /evidence=ECO:0000305	298..303		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920