Protein Alignment spo and CYP2C18

DIOPT Version :10

• Sequence 1: NP_647975.2
• Gene: spo / 38631
• FlyBaseID: FBgn0003486
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_000763.1
• Gene: CYP2C18 / 1562
• HGNCID: 2620
• Length: 490
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 139/502 - (27%)
• Similarity: 226/502 - (45%)
• Gaps: 100/502 - (19%)

  Fly    57 GPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVM 121
            ||.|.|||||:..|| .:|.. ...|..::.||.::::.||....:|::..|.::|.|..:|:..
Human    32 GPTPLPIIGNILQLD-VKDMS-KSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEF 94

  Fly   122 SGRPDFIRYHK-------LF-GGERSNSLALCDWSQLQQKRRNLARRHC--SPREFSCFYMKMSQ 176
            |||..|....|       || .|:|        |.::        ||.|  :.|.|.
Human    95 SGRGSFPVAEKVNKGLGILFSNGKR--------WKEI--------RRFCLMTLRNFG-------- 135

  Fly   177 IGCEEMEHWNRELGNQLVP------GEPINIKPLILKACANMFSQYMCSL----RFDYDDVDFQQ 231
            :|...:|...:|....||.      ..|.:  |..:..||.  ...:||:    ||||.|..|..
Human   136 MGKRSIEDRVQEEARCLVEELRKTNASPCD--PTFILGCAP--CNVICSVIFHDRFDYKDQRFLN 196

  Fly   232 IVQYFDEIF------W-EINQGHP--LDFLPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHREL 287
            :::.|:|..      | ::....|  :|:||..:       |||....:.|:.:::|||..|:|
Human   197 LMEKFNENLRILSSPWIQVCNNFPALIDYLPGSH-------NKIAENFAYIKSYVLERIKEHQE- 253

  Fly   288 SVDLDEPDRDFTDALLKSLLEDK-----DVSRNTIIFMLEDFIG-GHSAVGNLVMLVLAYIAKNV 346
            |:|::.. |||.|..|..:.::|     :.:..::|..:.|..| |.......:...|..:.|..
Human   254 SLDMNSA-RDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYP 317

  Fly   347 DIGRRIQEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYSS--SPIVPHVATEDTVISGYGV 409
            ::..::||||:.:: ..|||..:.|.:.||||.|.:.|:.||..  ...:||..|.|.....|.:
Human   318 EVTAKVQEEIECVV-GRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLI 381

  Fly   410 TKGTIVFINNYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPH 474
            .|||.:..:...:..::|.:.||:.|:|..||:.|     .|.|.||                 :
Human   382 PKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKS-----GNFKKSD-----------------Y 424

  Fly   475 FLPFSIGKRTCIGQNLVRGFGFLVVVNVMQRYNISSH-NPSTIKISP 520
            |:|||.|||.|:|:.|.|...||.:..::|.:|:.|. :|..|.|:|
Human   425 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITP 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_647975.2	CYP1_2-like	89..520	CDD:410710	125/468 (27%)
CYP2C18	NP_000763.1	CYP2C-like	61..485	CDD:410758	127/471 (27%)