DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spo and CYP2C9

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_000762.2	Gene:	CYP2C9 / 1559	HGNCID:	2623	Length:	490	Species:	Homo sapiens

Alignment Length:	511	Identity:	134/511 - (26%)
Similarity:	227/511 - (44%)	Gaps:	101/511 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PGPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKV 120
            |||.|.|:|||: |....:|.. ...|.|::.||.:::|.||....:|::..|.::|.|...|:.
Human    31 PGPTPLPVIGNI-LQIGIKDIS-KSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEE 93

  Fly   121 MSGR---PDFIRYHKLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEM 182
            .|||   |...|.::.||...||..   .|.::              |.||...::...:|...:
Human    94 FSGRGIFPLAERANRGFGIVFSNGK---KWKEI--------------RRFSLMTLRNFGMGKRSI 141

  Fly   183 EHWNRELGNQLV------PGEPINIKPLILKACA--NMFSQYMCSLRFDYDDVDFQQIVQYFDEI 239
            |...:|....||      ...|.:  |..:..||  |:....:...||||.|..|..:::
Human   142 EDRVQEEARCLVEELRKTKASPCD--PTFILGCAPCNVICSIIFHKRFDYKDQQFLNLME----- 199

  Fly   240 FWEINQGHPLDFLPW---------LYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPD 295
              ::|:...:...||         :..::....||::...:.::.:|:|::..|:| |:|::.|
Human   200 --KLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQE-SMDMNNP- 260

  Fly   296 RDFTDALLKSLLEDK---------DVSRNTIIFMLEDFIG-GHSAVGNLVMLVLAYIAKNVDIGR 350
            :||.|..|..:.::|         :...||.:    |..| |.......:...|..:.|:.::..
Human   261 QDFIDCFLMKMEKEKHNQPSEFTIESLENTAV----DLFGAGTETTSTTLRYALLLLLKHPEVTA 321

  Fly   351 RIQEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYSS--SPIVPHVATEDTVISGYGVTKGT 413
            ::||||:.:| ..|||..:.|.:.||||.|.:.||.||..  ...:||..|.|.....|.:.|||
Human   322 KVQEEIERVI-GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGT 385

  Fly   414 IVFIN-NYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLP 477
            .:.|: ..||:.:::| .||:.|:|..||:                 |..|.|     ...:|:|
Human   386 TILISLTSVLHDNKEF-PNPEMFDPHHFLD-----------------EGGNFK-----KSKYFMP 427

  Fly   478 FSIGKRTCIGQNLVRGFGFLVVVNVMQRYNISSHNPSTIKISPESLALPADCFPLV 533
            ||.|||.|:|:.|.....||.:.:::|.:|:.|      .:.|::|    |..|:|
Human   428 FSAGKRICVGEALAGMELFLFLTSILQNFNLKS------LVDPKNL----DTTPVV 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	134/511 (26%)
CYP2C9	NP_000762.2	p450	30..487	CDD:306555	134/511 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920