Protein Alignment spo and CYP2C8

DIOPT Version :10

• Sequence 1: NP_647975.2
• Gene: spo / 38631
• FlyBaseID: FBgn0003486
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_000761.3
• Gene: CYP2C8 / 1558
• HGNCID: 2622
• Length: 490
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 148/514 - (28%)
• Similarity: 235/514 - (45%)
• Gaps: 96/514 - (18%)

  Fly    56 PGPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKV 120
            |||.|.|||||:..:| .:|. ...||..::.||.::::.||....:|.:..|.::|.|..||:.
Human    31 PGPTPLPIIGNMLQID-VKDI-CKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEE 93

  Fly   121 MSGR---PDFIRYHKLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEM 182
            .|||   |...|..|..|...||...   |.::              |.||...::...:|...:
Human    94 FSGRGNSPISQRITKGLGIISSNGKR---WKEI--------------RRFSLTTLRNFGMGKRSI 141

  Fly   183 EHWNRELGNQLV------PGEPINIKPLILKACA--NMFSQYMCSLRFDYDDVDFQQIVQYFDEI 239
            |...:|..:.||      ...|.:  |..:..||  |:....:...||||.|.:|..:::.|:|.
Human   142 EDRVQEEAHCLVEELRKTKASPCD--PTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNEN 204

  Fly   240 FWEINQGHPLDFLPWL-----YP-----FYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEP 294
            |..:|.       ||:     :|     |...| ||::...:..|.:|.|::..| :.|:|::.|
Human   205 FRILNS-------PWIQVCNNFPLLIDCFPGTH-NKVLKNVALTRSYIREKVKEH-QASLDVNNP 260

  Fly   295 DRDFTDALLKSLLEDKDVSRNTIIFMLED--------FIGGHSAVGNLVMLVLAYIAKNVDIGRR 351
             |||.|..|..:.::||..::.  |.:|:        |:.|.......:...|..:.|:.::..:
Human   261 -RDFIDCFLIKMEQEKDNQKSE--FNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAK 322

  Fly   352 IQEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYSS-SPI-VPHVATEDTVISGYGVTKG-T 413
            :|||||.:| ..:||..:.|.:.||||.|.:.|:.|||. .|. |||..|.||....|.:.|| |
Human   323 VQEEIDHVI-GRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTT 386

  Fly   414 IVFINNYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPF 478
            |:.:...||:..::| .||..|:|..||:.:     .|.|.||                 :|:||
Human   387 IMALLTSVLHDDKEF-PNPNIFDPGHFLDKN-----GNFKKSD-----------------YFMPF 428

  Fly   479 SIGKRTCIGQNLVRGFGFLVVVNVMQRYNISS----HNPSTIKISPESLALPAD---CF 530
            |.|||.|.|:.|.|...||.:..::|.:|:.|    .|.:|..::...::||..   ||
Human   429 SAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICF 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_647975.2	CYP1_2-like	89..520	CDD:410710	130/466 (28%)
CYP2C8	NP_000761.3	CYP2C-like	61..485	CDD:410758	133/478 (28%)