Protein Alignment spo and CYP2A7

DIOPT Version :10

• Sequence 1: NP_647975.2
• Gene: spo / 38631
• FlyBaseID: FBgn0003486
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: XP_054175989.1
• Gene: CYP2A7 / 1549
• HGNCID: 2611
• Length: 572
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 122/566 - (21%)
• Similarity: 206/566 - (36%)
• Gaps: 174/566 - (30%)

  Fly    12 ILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNL------HLL 70
            :|:::||    |:...|...|.|..|::...            .|||.|.|.|||.      |:.
Human     7 LLVALLA----CLTVMVLMSVWQQRKSRGKL------------PPGPTPLPFIGNYLQLNTEHIC 55

  Fly    71 DRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPD-------FI 128
            |        ....::::||.::::..|..|.:|:...:.:||.|....:..|||.:       |.
Human    56 D--------SIMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFK 112

  Fly   129 RYHKLF-GGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQ 192
            .|..:| .|||:..|                      |.||...::...:|...:|...:|....
Human   113 GYGVVFSNGERAKQL----------------------RRFSIATLRDFGVGKRGIEERIQEEAGF 155

  Fly   193 LVPGEPI------NIKP--LILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEI--FWEINQGH 247
            |:  |.|      ||:|  .:.:..:|:.|..:...||||:|.:|..::.....|  |...:.|.
Human   156 LI--EAIRSTHGANIEPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQ 218

  Fly   248 PLDFLPWLYPFY---QRHL----NKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDA-LLK 304
                   ||..:   .:||    .:.......:..||.:: :.|.:.::|.:.| :||.|: |::
Human   219 -------LYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKK-VEHNQRTLDPNSP-QDFIDSFLIR 274

  Fly   305 SLLEDKDVS-----RNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEEN 364
            ...|:|:.:     :|.::..|..||.|...|...:......:.|:.::..::.||||.:| .:|
Human   275 MQEEEKNPNTEFYLKNLMMTTLNLFIAGTETVSTTLCYGFLLLMKHPEVEAKVHEEIDRVI-GKN 338

  Fly   365 RSINLLDMNAMPYTMATIFEVLRYSSSPIVPHVATEDTVISGYGVTKGTIVFINNYVLNTSEKFW 429
            |.....|...|||..|.|.|:.|:..  ::|       :.....|.|.|             ||
Human   339 RQPKFEDRTKMPYMEAVIHEIQRFGD--VIP-------MSLARRVKKDT-------------KF- 380

  Fly   430 VNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLP-----FSI------GKR 483
               ::|    ||.......|...:|           |.....:|..||     :|:      .||
Human   381 ---RDF----FLPKVLSSPPPRLRG-----------LPALLCVPRILPPLEAFYSLSHSLNQSKR 427

  Fly   484 TCIGQNLVRGFGFLVVVNVMQRYNISSHNPSTIKISPESLALPADC 529
            |                           :|:|..|.|..|..|..|
Human   428 T---------------------------SPTTTSIPPFHLDTPESC 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_647975.2	CYP1_2-like	89..520	CDD:410710	99/472 (21%)
CYP2A7	XP_054175989.1	cytochrome_P450	65..>387	CDD:477761	87/385 (23%)