Protein Alignment spo and CYP1B1

DIOPT Version :9

• Sequence 1: NP_001286943.1
• Gene: spo / 38631
• FlyBaseID: FBgn0003486
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_000095.2
• Gene: CYP1B1 / 1545
• HGNCID: 2597
• Length: 543
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 150/566 - (26%)
• Similarity: 255/566 - (45%)
• Gaps: 93/566 - (16%)

  Fly     8 TILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHLLDR 72
            |.|.:|||||||.:      |.:|:|:           ....|..:..|||..||:|||...:.:
Human    21 TTLLLLLSVLATVH------VGQRLLR-----------QRRRQLRSAPPGPFAWPLIGNAAAVGQ 68

  Fly    73 YRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKLFGGE 137
               :....|..||::|||::.:..|....:|:|....|.:.|.|.|...:.||.|..:..:.||
Human    69 ---AAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGG- 129

  Fly   138 RSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLVPGEP---- 198
              .|:|...:|:..:.:|..|  |...|.|.....:..|:....:....|||...||.|..
Human   130 --RSMAFGHYSEHWKVQRRAA--HSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAF 190

  Fly   199 INIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHPLDFLPWLYPFYQ--- 260
            ::.:||.:.|.||:.|......|:.:||.:|::::.:.:|....:..|..:|.:|||..|..
Human   191 LDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVR 255

  Fly   261 ------RHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLKSL------------- 306
                  ..||:  |:|:    ||:::.:||.| |:......||..||.:.|.
Human   256 TVFREFEQLNR--NFSN----FILDKFLRHCE-SLRPGAAPRDMMDAFILSAEKKAAGDSHGGGA 313

  Fly   307 ---LEDKDVSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSIN 368
               ||:...:...|....:|.:.  :|:..|::|...|    .|:..|:|.|:|.::..: |...
Human   314 RLDLENVPATITDIFGASQDTLS--TALQWLLLLFTRY----PDVQTRVQAELDQVVGRD-RLPC 371

  Fly   369 LLDMNAMPYTMATIFEVLRYSS-SPI-VPHVATEDTVISGYGVTKGTIVFINNYVLNTSEKFWVN 431
            :.|...:||.:|.::|.:|:|| .|: :||..|.:|.:.||.:.|.|:||:|.:.:|.....|.|
Human   372 MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPN 436

  Fly   432 PKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNL--VRGF 494
            |:.|:|.|||                    |.:.|..|......:.||:|||.|||:.|  ::.|
Human   437 PENFDPARFL--------------------DKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLF 481

  Fly   495 GFLVVVNVMQRYNISSHNPSTIKISPESLALPADCFPLVLTPREKI 540
            .|:.::.....:..:.:.|:.:..| ..|.:....|.:.:|.||.:
Human   482 LFISILAHQCDFRANPNEPAKMNFS-YGLTIKPKSFKVNVTLRESM 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	137/516 (27%)
CYP1B1	NP_000095.2	p450	51..520	CDD:365848	134/511 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4653
OMA	1	1.010	-	-		QHG45226
OrthoDB	1	1.010	-	-		D278622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.880