Protein Alignment spo and CYP1A2

DIOPT Version :10

• Sequence 1: NP_647975.2
• Gene: spo / 38631
• FlyBaseID: FBgn0003486
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_000752.2
• Gene: CYP1A2 / 1544
• HGNCID: 2596
• Length: 516
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 143/534 - (26%)
• Similarity: 231/534 - (43%)
• Gaps: 90/534 - (16%)

  Fly    16 VLATSYICIIY----GVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHLLDRYRDS 76
            :||::..|:::    |::.||.:.:|:                .|.|..||::|::..|.:   :
Human    15 LLASAIFCLVFWVLKGLRPRVPKGLKS----------------PPEPWGWPLLGHVLTLGK---N 60

  Fly    77 PFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKLFGGERSNS 141
            |....:.::|:|||:..:..|.|..||::.|:.||:.|.:.|....||||......:..|:   |
Human    61 PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQ---S 122

  Fly   142 LAL-CDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELG------NQLVPG--- 196
            |.. .|...:...||.||:.  :...||......|...|...||.::|..      .:|:.|
Human   123 LTFSTDSGPVWAARRRLAQN--ALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGH 185

  Fly   197 -EPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHPLDFLPWL----Y 256
             :|.|   .::.:.||:.........|.....:...:|:...|.....:.|:||||.|.|    .
Human   186 FDPYN---QVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPN 247

  Fly   257 PFYQRH--LNKIINWSSTIRGFIMERIIRHRELSVDLDEPD-RDFTDALLKSLLEDKDVSRN--- 315
            |..||.  .|:...|      |:.:.:..|.:   |.|:.. ||.|.||.|...:....|.|
Human   248 PALQRFKAFNQRFLW------FLQKTVQEHYQ---DFDKNSVRDITGALFKHSKKGPRASGNLIP 303

  Fly   316 --TIIFMLEDFIG-GHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDMNAMPY 377
              .|:.::.|..| |...|...:...|.|:....:|.|:||:|:|.:|..|.|. .|.|...:||
Human   304 QEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRP-RLSDRPQLPY 367

  Fly   378 TMATIFEVLRYSS-SPI-VPHVATEDTVISGYGVTKGTIVFINNYVLNTSEKFWVNPKEFNPLRF 440
            ..|.|.|..|:|| .|. :||..|.||.::|:.:.|...||:|.:.:|...:.|.:|.||.|.||
Human   368 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERF 432

  Fly   441 LEPSKEQSPKNSKGSDSGIESD-NEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVVVNVMQ 504
            |           ....:.|... :||:.|         |.:|||.|||:.|.:...||.:..::|
Human   433 L-----------TADGTAINKPLSEKMML---------FGMGKRRCIGEVLAKWEIFLFLAILLQ 477

  Fly   505 RYNISSHNPSTIKI 518
            :...|.  |..:|:
Human   478 QLEFSV--PPGVKV 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_647975.2	CYP1_2-like	89..520	CDD:410710	127/457 (28%)
CYP1A2	NP_000752.2	CYP1A	72..506	CDD:410769	128/458 (28%)