Protein Alignment spo and Cyp2e1

DIOPT Version :9

• Sequence 1: NP_001286943.1
• Gene: spo / 38631
• FlyBaseID: FBgn0003486
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_067257.1
• Gene: Cyp2e1 / 13106
• MGIID: 88607
• Length: 493
• Species: Mus musculus
• Alignment Length: 551
• Identity: 144/551 - (26%)
• Similarity: 247/551 - (44%)
• Gaps: 99/551 - (17%)

  Fly    25 IYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYG 89
            :.|:...:|..:.|.....|....|:.:...|||.|.|..||:..|| .:|.| ...|.||:::|
Mouse     3 VLGITVALLVWIATLLLVSIWKQIYRSWNLPPGPFPIPFFGNIFQLD-LKDIP-KSLTKLAKRFG 65

  Fly    90 DIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGR---PDFIRYHK---LFGG-------ERSNS 141
            .:::|..|..|.:|::..:.::|||..:....|||   |.|..|..   :|..       .|.:.
Mouse    66 PVFTLHLGQRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSL 130

  Fly   142 LALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLVPGEPINIKPLIL 206
            ..|.||.  ..|:.|.||           ..:.:....||::.         ..|:|.:  |..|
Mouse   131 SILRDWG--MGKQGNEAR-----------IQREAHFLVEELKK---------TKGQPFD--PTFL 171

  Fly   207 KACA--NMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHPLDFLPWL--YPFYQRHL---- 263
            ..||  |:.:..:.:.||||||....:::..|:|.|:.::       .||:  |.::..:|
Mouse   172 IGCAPCNVIADILFNKRFDYDDKKCLELMSLFNENFYLLS-------TPWIQAYNYFSDYLQYLP 229

  Fly   264 ---NKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLKSLLEDKD------VSRNTIIF 319
               .|::...|.||.:.:.:...|.: |:|::.| ||.||.||..:.::|.      ...|..:.
Mouse   230 GSHRKVMKNVSEIRQYTLGKAKEHLK-SLDINCP-RDVTDCLLIEMEKEKHSQEPMYTMENISVT 292

  Fly   320 MLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDMNAMPYTMATIFE 384
            :.:.|..|.......:...|..:.|..:|..::.||||.:| ..:|:..:.|...|||..|.:.|
Mouse   293 LADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVI-GPSRAPAVRDRMNMPYMDAVVHE 356

  Fly   385 VLRYSS--SPIVPHVATEDTVISGYGVTKGTIVF--INNYVLNTSEKFWVNPKEFNPLRFLEPSK 445
            :.|:.:  ...:||.||.|||..||.:.|||:|.  :::.:.:..|  :.:|:.|.|..||
Mouse   357 IQRFINLVPSNLPHEATRDTVFRGYVIPKGTVVIPTLDSLLFDNYE--FPDPETFKPEHFL---- 415

  Fly   446 EQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVVVNVMQRYNISS 510
                             ||..:.|.: .:|..||.|||.|:|:.|.|...||::..::|.:|:.|
Mouse   416 -----------------NENGKFKYS-DYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKS 462

  Fly   511 -HNPSTIKISPESL---ALPADCFPLVLTPR 537
             .:|..|.:||.::   ::|.: |.|.:.||
Mouse   463 LVDPKDIDLSPVTIGFGSIPRE-FKLCVIPR 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	139/520 (27%)
Cyp2e1	NP_067257.1	p450	44..489	CDD:278495	131/505 (26%)
		Substrate binding. /evidence=ECO:0000250	298..303		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010