DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2d9

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_034136.2	Gene:	Cyp2d9 / 13105	MGIID:	88606	Length:	504	Species:	Mus musculus

Alignment Length:	553	Identity:	132/553 - (23%)
Similarity:	238/553 - (43%)	Gaps:	100/553 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IYTILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQ--APGPRPWPIIGNLH 68
            |:|::.|||                           .::.|.. |::|.  .|||.|||::|||.
Mouse    14 IFTVIFILL---------------------------VDLTHQR-QRWTSRYPPGPVPWPVLGNLL 50

  Fly    69 LLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDFIRYHKL 133
            .:| ..:.|::.: .|..:|||::||.......:|:|.|:.::|:|...|:..:.||....:..|
Mouse    51 QVD-LGNMPYSLY-KLQNRYGDVFSLQMAWKPMVVINGLKAMKEMLLTCGEDTADRPPVPIFEYL 113

  Fly   134 FGGERSNSLALC----DWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLV 194
            .....|..:.|.    :|.:              .|.||...::...:|.:.:|.|..:..|.|.
Mouse   114 GVKPGSQGVVLAPYGPEWRE--------------QRRFSVSTLRNFGLGKKSLEDWVTKEANHLC 164

  Fly   195 ------PGEPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIFWEINQGHP--LDF 251
                  .|:|||..|::.|:..|:.:..:.:.||:|:|....::::..::...|::...|  |:.
Mouse   165 DAFTAQAGQPINPNPMLNKSTCNVIASLIFARRFEYEDPFLIRMLKVLEQSLTEVSGLIPEVLNA 229

  Fly   252 LPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLKSLLEDK-----D 311
            .|.|... .|..:|.:....:... |::.::.....:.|..:..|:.|||.|..:.:.|     .
Mouse   230 FPILLRI-PRLADKALQGQKSFIA-ILDNLLTENRTTWDPVQAPRNLTDAFLAEIEKAKGNPESS 292

  Fly   312 VSRNTIIFMLEDFIG-GHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDMNAM 375
            .:...::.::.|..| |.......:...|..:..:.|:.||:|:|||.:|.:. |...:.|...|
Mouse   293 FNDENLLMVVRDLFGAGMLTTSTTLSWALMLMILHPDVQRRVQQEIDEVIGQV-RHPEMADQAHM 356

  Fly   376 PYTMATIFEVLRYSS-SPI-VPHVATEDTVISGYGVTKGTIVFINNYVLNTSEKFWVNPKEFNPL 438
            |||.|.|.||.|:.. .|: :|.:.:.|..:..:.:.||||:..|...:...|..|..|..|:|.
Mouse   357 PYTNAVIHEVQRFGDIVPVNLPRITSHDIEVQDFLIPKGTILLPNMSSMLKDESVWEKPLRFHPE 421

  Fly   439 RFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVVVNVM 503
            .||:         ::|.....|:             |:|||.|:|:|:|:.|.|...||....::
Mouse   422 HFLD---------AQGHFVKPEA-------------FMPFSAGRRSCLGEALARMELFLFFTCLL 464

  Fly   504 QRYNIS----SHNPST-----IKISPESLALPA 527
            ||::.|    ...||.     |.::|....|.|
Mouse   465 QRFSFSVPDGQPQPSNSGVYGILVAPSPYQLCA 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	124/501 (25%)
Cyp2d9	NP_034136.2	p450	37..496	CDD:278495	122/499 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920