DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2c39

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001360866.1	Gene:	Cyp2c39 / 13098	MGIID:	1306818	Length:	490	Species:	Mus musculus

Alignment Length:	522	Identity:	142/522 - (27%)
Similarity:	228/522 - (43%)	Gaps:	102/522 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PGPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKV 120
            |||.|:|||||...:|....|  ...|..::.||.:::|..|....:|::..|.::|.|..:|:.
Mouse    31 PGPTPFPIIGNFLQIDGKNFS--QSLTNFSKAYGPVFTLYLGSRPTVVLHGYEAVKEALIDHGEE 93

  Fly   121 MSGRPDFIRYHKLFGGERSNSLALC-----DWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCE 180
            .|.|.......|:     :|.|.:.     .|.::              |.|:...::...:|..
Mouse    94 FSDRGSIPMVEKI-----NNGLGIVFSNGNRWKEI--------------RRFTLTTLRNLGMGKR 139

  Fly   181 EMEHWNRELGNQLV------PGEPINIKPLILKACANMFSQYMCSL----RFDYDDVDFQQIVQY 235
            .:|...:|....||      .|.|.:  |..:.:||.  ...:||:    ||||.|.||..:::
Mouse   140 NIEDRVQEEAQCLVEELRKTKGSPCD--PTFILSCAP--CNVICSIIFQDRFDYKDKDFLMLME- 199

  Fly   236 FDEIFWEINQGHPLDFLPWL-----YPFYQRHL----NKIINWSSTIRGFIMERIIRHRELSVDL 291
                  ::|:...:...|||     :|....:.    :|::.....||.:::|:|..|:| |:|:
Mouse   200 ------KLNENVKILSSPWLQVCNNFPLLIDYCPGSHHKVLKNVKYIRSYLLEKIKEHQE-SLDV 257

  Fly   292 DEPDRDFTDALLKSLLEDKDVSR-NTIIFMLED--------FIGGHSAVGNLVMLVLAYIAKNVD 347
            ..| |||.|..   |::.|..:. ....|.||:        |..|.......:...|..:.|..|
Mouse   258 TNP-RDFIDYY---LIKQKQANHIQQAEFSLENLACTINNLFAAGTETTSTTLRYALLLLMKYPD 318

  Fly   348 IGRRIQEEIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYSS--SPIVPHVATEDTVISGYGVT 410
            :..::|||||.:| ..:||..:.|.|.||||.|.|.||.|:.:  ...:|...|.|.....|.:.
Mouse   319 VTAKVQEEIDHVI-GRHRSPCMQDRNHMPYTDAMIHEVQRFINLVPNNIPRAVTCDIKFRNYLIP 382

  Fly   411 KGTIVFIN-NYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPH 474
            |||.|..: ..||:.|::| .||:.|:|..||:.:     .|.|.||                 |
Mouse   383 KGTTVVTSLTSVLHDSKEF-PNPELFDPGHFLDAN-----GNFKKSD-----------------H 424

  Fly   475 FLPFSIGKRTCIGQNLVRGFGFLVVVNVMQRYNISS-HNPSTIKISP---ESLALPADCFPLVLT 535
            |:|||.|||.|.|:.|.|...||.:..::|.:.:.| .:|..|.:.|   ..:|||.. :.:.:.
Mouse   425 FMPFSAGKRVCAGEGLARMELFLFLTTILQNFKLKSLVHPKDIDMIPFVNGLIALPPH-YQVCII 488

  Fly   536 PR 537
            ||
Mouse   489 PR 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	142/522 (27%)
Cyp2c39	NP_001360866.1	p450	30..487	CDD:365848	140/517 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920