DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2c37

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_034131.2	Gene:	Cyp2c37 / 13096	MGIID:	1306806	Length:	490	Species:	Mus musculus

Alignment Length:	515	Identity:	146/515 - (28%)
Similarity:	235/515 - (45%)	Gaps:	90/515 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PGPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKV 120
            |||.|.|||||:..:| .:|. ...||.|::.||.:|:|..|....:|::..|.::|.|..:|:.
Mouse    31 PGPTPLPIIGNILQID-VKDI-CQSFTNLSKVYGPVYTLYLGRKPTVVLHGYEAVKEALVDHGEE 93

  Fly   121 MSGRPDFIRYHKLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHW 185
            .:||..|..:.|...|   ..||....:..:..||           ||...::...:|...:|..
Mouse    94 FAGRGRFPVFDKATNG---MGLAFSKGNVWKNTRR-----------FSLMTLRNLGMGKRSIEDR 144

  Fly   186 NRELGNQLVP------GEPINIKPLILKACANMFSQYMCSL----RFDYDDVDFQQIVQYFDEIF 240
            .:|....||.      |.|.:  |..:..||.  ...:||:    ||||.|.||..:::..:||.
Mouse   145 VQEEARCLVEELRKTNGSPCD--PTFILGCAP--CNVICSIIFQDRFDYKDRDFLNLMEKLNEIT 205

  Fly   241 ------W-EINQGHP--LDFLPWLY-PFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPD 295
                  | :|...:|  ||:.|..: .|::.:        ::|:.|::|:|..|.| |:|:..|
Mouse   206 KILSSPWLQICNTYPALLDYCPGSHKQFFKNY--------ASIKNFLLEKIKEHEE-SLDVTIP- 260

  Fly   296 RDFTD-ALLKSLLED-----KDVSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQE 354
            |||.| .|:....||     ::...:..|.:.:.|..|.......:...:..:.|...:..::||
Mouse   261 RDFIDYFLINGGQEDGNQPLQNRLEHLAITVTDLFSAGTETTSTTLRYAILLLLKYPHVTAKVQE 325

  Fly   355 EIDAIIEEENRSINLLDMNAMPYTMATIFEVLRYSS--SPIVPHVATEDTVISGYGVTKGTIVFI 417
            ||:.:| .::||..:.|.:.||||.|.|.||.|:..  ...:||..|.|.....|.:.|||.|..
Mouse   326 EIEHVI-GKHRSPCMQDRSRMPYTDAMIHEVQRFIDLIPNSLPHEVTSDIKFRNYFIPKGTTVIT 389

  Fly   418 N-NYVLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIG 481
            : :.||:.|.:| .||::|:|..||:       :|.|...|               .:|:|||.|
Mouse   390 SLSSVLHDSTEF-PNPEKFDPGHFLD-------ENGKFKKS---------------DYFIPFSTG 431

  Fly   482 KRTCIGQNLVRGFGFLVVVNVMQRYNISS-HNPSTIKISPESLAL----PADCFPLVLTP 536
            ||.|.|:.|.|...||.:.:::|.:|:.. .:|..|.::|..:.|    ||  |.|...|
Mouse   432 KRICAGEGLARMELFLFLTSILQNFNLKPLVHPKDIDVTPMLIGLASVPPA--FQLCFIP 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	146/515 (28%)
Cyp2c37	NP_034131.2	p450	30..487	CDD:278495	145/511 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920