DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spo and Cyp2b19

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_031840.1	Gene:	Cyp2b19 / 13090	MGIID:	107303	Length:	492	Species:	Mus musculus

Alignment Length:	553	Identity:	146/553 - (26%)
Similarity:	230/553 - (41%)	Gaps:	126/553 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHLLDRYRDS 76
            :||..|.|.::..:....    || ||       |..:     .|||||.|.:|||..:|  |..
Mouse     6 LLLLALTTGFLIFLVSQS----QP-KT-------HGHF-----PPGPRPLPFLGNLLQMD--RRG 51

  Fly    77 PFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGR-------PDFIRYHKLF 134
            ..:.|..|.::|||::::..|....:::...:.|||.|....:..|||       |....|..:|
Mouse    52 LLSSFIQLQEKYGDVFTVHLGPRPVVMLCGTDTIREALVNQAEAFSGRGTVAVLDPIVQGYGVIF 116

  Fly   135 -GGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLV---- 194
             .|||        |..|              |.||...|:...:|...:|...:|....||
Mouse   117 SSGER--------WKTL--------------RRFSLATMRDFGMGKRSVEERIKEEAQCLVEELK 159

  Fly   195 --PGEPINIKPLILKAC--ANMFSQYMCSLRFDYDDVDF----QQIVQYFD----------EIFW 241
              .|.|:|  |.....|  ||:....:...||||.|..|    ..|.|.|.          |:|.
Mouse   160 KYKGAPLN--PTFYFQCIVANIICSIVFGERFDYKDHQFLHLLNLIYQTFSLMSSLSSQVFELFS 222

  Fly   242 EINQGHPLDFLPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLKSL 306
            .|     |.:.|..:....::|.:|::       :|...:.:|| .::|...| |||.|..|..:
Mouse   223 AI-----LKYFPGAHRQISKNLQEILD-------YIGHSVEKHR-ATLDPSAP-RDFIDTYLLRM 273

  Fly   307 LEDKD------VSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENR 365
            .::|.      ..:|.:|.:|..|..|.......:......:.|...:..::|:|||.:| ..:|
Mouse   274 EKEKSNHHTEFHHQNLVISVLSLFFAGTETTSTTLRYSFLIMLKYPHVAEKVQKEIDQVI-GSHR 337

  Fly   366 SINLLDMNAMPYTMATIFEVLRYSS-SPI-VPHVATEDTVISGYGVTKGTIVF-INNYVLNTSEK 427
            ...|.|...||||.|.|.|:.|::. :|| :||..|:||:..||.:.|.|.|: |.:..|: ..:
Mouse   338 LPTLDDRTKMPYTDAVIHEIQRFTDLAPIGLPHKVTKDTLFRGYLIPKNTEVYPILSSALH-DPR 401

  Fly   428 FWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVR 492
            ::..|..|||..||:.             :|....||.         |:|||.|||.|:|:.:.|
Mouse   402 YFEQPDSFNPEHFLDA-------------NGALKTNEA---------FMPFSTGKRICLGEGIAR 444

  Fly   493 GFGFLVVVNVMQRYNISSHNPSTIKISPESLAL 525
            ...||....::|.::::|      .::||::.|
Mouse   445 NELFLFFTTILQNFSLAS------PVAPENIDL 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	137/509 (27%)
Cyp2b19	NP_031840.1	p450	32..487	CDD:278495	137/510 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010