DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spo and Cyp2b13

DIOPT Version :9

Sequence 1:	NP_001286943.1	Gene:	spo / 38631	FlyBaseID:	FBgn0003486	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_006539571.1	Gene:	Cyp2b13 / 13089	MGIID:	88599	Length:	517	Species:	Mus musculus

Alignment Length:	565	Identity:	143/565 - (25%)
Similarity:	235/565 - (41%)	Gaps:	159/565 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRPWPIIGNLHLLDRYRDSPFAGFTALAQQYG 89
            :||...:.:.....:|:..|.|        ||             ||:          .|.:::|
Mouse    56 VYGAVEQTMDVRGKQNALVIQH--------AP-------------LDQ----------RLQEKHG 89

  Fly    90 DIYSLTFGHTRCLVVNNLELIREVLNQNGKVMSGRPDF------IRYHKLF--GGERSNSLALCD 146
            |::::..|....:|:...:.|||.|..|.:..|||...      ::.:.:|  .|||
Mouse    90 DVFTVHLGPRPVVVLCGTQTIREALVNNAEAFSGRGTIAAAQLVMQDYGIFFSSGER-------- 146

  Fly   147 WSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCEEMEHWNRELGNQLV------PGEPINIKPLI 205
            |..|              |.||...||...:|...:|...:|....||      .|.|::  |..
Mouse   147 WKTL--------------RRFSLATMKEFGMGKRSVEERIKEEAQCLVEELKKYQGAPLD--PTF 195

  Fly   206 LKAC--ANMFSQYMCSLRFDYDDVDFQQIVQYFDEIF----------WEINQGHPLDFLPWLYPF 258
            ...|  ||:....:...||||.|..|.:::....:|:          :|:..| .|.:.|.::..
Mouse   196 FFQCVTANIICSIVFGERFDYTDEQFLRLLNLMYQIYSLLRSFSCQMFELFSG-LLKYFPGVHRQ 259

  Fly   259 YQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTDALLKSLLEDKD------VSRNTI 317
            ..::..:|:|       ||..|:.:|| .::|..|| |||.|..|..:.::|.      ..:|.:
Mouse   260 IAKNQQEILN-------FITHRVEKHR-ATLDPSEP-RDFIDTYLLRMEKEKSNHNTEFHHQNLM 315

  Fly   318 IFMLEDFIGGHSAV------GNLVMLVLAYIAKNVDIGRRIQEEIDAIIEEENRSINLLDMNAMP 376
            :.:|..|..|....      |.|:||:..::|:      ::|:|||.:| ..:|...|.|...||
Mouse   316 MSVLSLFFAGTETTSTTLCCGFLLMLMYPHVAE------KVQKEIDQVI-GSHRLPTLDDRTKMP 373

  Fly   377 YTMATIFEVLRYSSSPIV----PHVATEDTVISGYGVTKGTIVF-INNYVLNTSEKFWVNPKEFN 436
            ||.|.|.|:.|:|.  ||    ||..|:||:..||.:.|.|.|: |.:..|: ..:::..|..||
Mouse   374 YTDAVIHEIQRFSD--IVPTGAPHRVTKDTMFRGYLLPKNTEVYPILSSALH-DPQYFEQPDSFN 435

  Fly   437 PLRFLEPSKEQSPKNSKGSDSGIESDNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLVVVN 501
            |..||:         :.|:            ||:: ..|||||.|||.|:|:::.|...||...:
Mouse   436 PDHFLD---------ANGA------------LKKS-EAFLPFSTGKRICLGESIARNELFLFFTS 478

  Fly   502 VMQRYNISSHNPSTIKISPESLALPADCFPLVLTPRE----KIGP 542
            ::|.::::|               |.....:.|||:|    ||.|
Mouse   479 ILQNFSVAS---------------PVASKDIDLTPKESGIGKIPP 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spo	NP_001286943.1	p450	56..540	CDD:299894	134/530 (25%)
Cyp2b13	XP_006539571.1	p450	82..514	CDD:365848	134/518 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010