DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)psg2 and toporsb

DIOPT Version :9

Sequence 1:	NP_647974.1	Gene:	l(3)psg2 / 38630	FlyBaseID:	FBgn0035617	Length:	1929	Species:	Drosophila melanogaster
Sequence 2:	XP_003201680.1	Gene:	toporsb / 796087	ZFINID:	ZDB-GENE-110728-3	Length:	939	Species:	Danio rerio

Alignment Length:	1009	Identity:	187/1009 - (18%)
Similarity:	331/1009 - (32%)	Gaps:	384/1009 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 KVKNKDTNEENANKKLRERSKDRN-----------HSKER---------LHERTQNKSEERKPEA 529
            :|:.||:..:.:.:.|...|.|..           .|.:|         :||.::||:|  .|..
Zfish     9 RVRKKDSASKTSQRLLANASPDSKCPICLDGFNNVASLDRCLHQFCFRCIHEWSKNKAE--CPLC 71

  Fly   530 KKVRNAIENSKEAPTDRKKDKLLGPLGEKTDERSKDKQIKRSREQSVTKCPKESGKDTLMEHPPQ 594
            |:..::|.:|.:...|.|:..|                           .|.|:|       ...
Zfish    72 KQPFHSIFHSVKGENDFKEFVL---------------------------WPPENG-------AAN 102

  Fly   595 ENGLDGSKRSSMPHESFSESAKTREHASRRKNQTLSPWGSREGTPPMTPPQVQIPQTPIVDIANP 659
            .|..|.|:|...|        :......||.|:.                     |||
Zfish   103 ANAADPSERVLRP--------RVLRRRERRSNRV---------------------QTP------- 131

  Fly   660 KDFDIFADSPPRVNTAVSAPAATIERSTTPPLKSSIPIVPIAKADKLAPLLKASEIHSRIGA--- 721
                              ||      |:|||::..:....::.|..||......::..|:.|
Zfish   132 ------------------AP------SSTPPIEDDVMFDGLSDAAALAENQDVQQMMLRLTARRA 172

  Fly   722 ---------LLEESDLHLDNLLATKEQLFRRTNEYKERKEA--PKEIKAEYLPNSRHNRSATGRA 775
                     .|.|.|     ::|.:..|:|.....:..::|  .::|.|.:|   |.|....
Zfish   173 GRGEGRSLRRLREQD-----VVAFRRALYRTGVRVRSARDASRQRDISASFL---RQNPGCL--- 226

  Fly   776 EVEHHKSQPRHINPF-KRE-SVLSGRKSS----------SRPSSKERRFQRHDSEVENWDRDLEL 828
                     |.:.|: :|| :||.|...|          ||              :.|::.:..:
Zfish   227 ---------RRLLPWLQRELTVLYGSHGSLVNIVQNVIISR--------------IMNYNMEESI 268

  Fly   829 ERNQLNGSQLTGFQPRKSDEYTKFSIKKEKDLTPPPLQTNFTRTTIKIERNATPPRHMEHDVLVR 893
            .|::|.     .|...::|.:....:             :|.|:::.:|         .:|:
Zfish   269 IRDELR-----PFLLARTDHFLHELV-------------SFARSSLNME---------AYDL--- 303

  Fly   894 NGAVATNAPPPAKEQESPDTDDYI---DNWENDDSLASMPKNAPPVTPTPAPNANASLNATPLPP 955
              ....:.|.|:.|:.|......|   ::.|::||..::.:|...|....|..|.||...:.|
Zfish   304 --QAVYDCPAPSYEEGSSSDLSVIAISEDEEDNDSENNVIENPSAVQERIASVATASGTDSLL-- 364

  Fly   956 VASQFNGDDDDDDSNALWNAKSTPPPRRKNENLPEGNIHELYDKFMNSIKMS-NEHLEPETLDTS 1019
              ||...||:            ||.|.              |...:.|...| :|..||
Zfish   365 --SQSAWDDE------------TPGPS--------------YSSILQSSNQSQDEGAEP------ 395

  Fly  1020 KNSSLSNSPAEESSSGTETSSTSSSSSETE--------------------DDSSSDDDANESSSN 1064
               |.|.:|...|:.||:.::.|::..|.|                    ...||:::..::::.
Zfish   396 ---SSSTAPPLASTDGTDPAAISAADEEEECLIVGYVKPMAERTPELVQLSSDSSEEEEQQAAAT 457

  Fly  1065 DESATTSGNCNTNQDEAAGKEQLQKKNNVSKDLRKLKSLEDNLARIQMMRENYDAGDEISEELLK 1129
            :..||.:       ....|:.||...::       :|.|..:.........:..|...:.:|:|.
Zfish   458 ETPATVT-------KSETGQSQLPLPSH-------MKPLSPSSFAGPAPSCSPQANPSVPQEILS 508

  Fly  1130 MESLFLMQRNAIMDKY--------------------RKQELKSNSSEDQQPVDEQGTVQAQEVVK 1174
                |..:|.:  |.|                    ||.....::.|..:.::     |.|:...
Zfish   509 ----FSRERES--DYYSSHGHRSRLASWSELRVHGRRKDRSHRHNKEKAKSIE-----QIQQPTT 562

  Fly  1175 ETSFPVNS--IFSANREAIKL-TISPLKLTRKSVIFDKDEADLPETSKAEPPKQTLQKPQKEIAI 1236
            ....|::|  .:|....|:.: :|||     .|..:|.|.:..|:|           |.:|....
Zfish   563 LECSPMHSPQSWSGQSSAVSICSISP-----GSPSYDSDYSPSPKT-----------KGRKHSCR 611

  Fly  1237 VKPTIVESRS-------KPKL-RSP----------PPSSGSRRRSRSRSISRSRARRRGSRTKSR 1283
            |:..|.:|.|       |.:: |||          |..|...|:.|.||:|.|.|.....::...
Zfish   612 VQERIRQSPSYSGRKSTKERMSRSPDLDLFIGSHHPRESKRHRKRRKRSVSSSSADSHSEKSCLD 676

  Fly  1284 TPSPRRRRLPSPRRVSRYAKRIGGGAVGGTRKGRSHSRSLTRSRTRSRSPSRRRRLPPAGHRKRG 1348
            .||.:|:.  ..|.:.|.|:|       ...:|.......::.|:|.|||
Zfish   677 KPSGKRKY--KTRHLERAAQR-------QHEEGNPSKEKRSKLRSRDRSP--------------- 717

  Fly  1349 SISPIPQKLAGPRSPPP---SRRRQSLSRDRERE 1379
            |:..|.::    |:|.|   ||:::...|.|.::
Zfish   718 SVEIIYER----RAPDPHWVSRKKKKKHRKRRKD 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)psg2	NP_647974.1	PRP38_assoc	374..450	CDD:289628
toporsb	XP_003201680.1	RING	32..75	CDD:238093	9/44 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579334
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930