DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(3)psg2 and SON

DIOPT Version :9

Sequence 1:NP_647974.1 Gene:l(3)psg2 / 38630 FlyBaseID:FBgn0035617 Length:1929 Species:Drosophila melanogaster
Sequence 2:NP_620305.3 Gene:SON / 6651 HGNCID:11183 Length:2426 Species:Homo sapiens


Alignment Length:1808 Identity:351/1808 - (19%)
Similarity:576/1808 - (31%) Gaps:541/1808 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   350 FRRKSRERSQDKNLNRAKSMNLSKEKDEVGGEPRNTASGKSQERDQSRGKTKDRSRERDRTRNKT 414
            ||...:|.|..:|            :.::.|| .||....:|..|.:   ...||...:....|.
Human    17 FREIQQELSSGRN------------EGQLNGE-TNTPIEGNQAGDAA---ASARSLPNEEIVQKI 65

  Fly   415 RE-KSQARD-QTRSKANDAEHTRAKSR--------------KRSSSRDKRREKSKEKLGDKEKNE 463
            .| .|...| :.|.|.:..|.:| |||              |:|....|.:.|.|:|..:|||..
Human    66 EEVLSGVLDTELRYKPDLKEGSR-KSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKY 129

  Fly   464 DLSKEKLEGKSTEHSE--------------------------------KRNES-------KVKNK 489
            ....|:.|.|:..|.:                                :.|||       .|.:.
Human   130 KRQPEESESKTKSHDDGNIDLESDSFLKFDSEPSAVALELPTRAFGPSETNESPAVVLEPPVVSM 194

  Fly   490 DTNEENANKKLRERSKDRN---HSKERLHERTQN-----------------------------KS 522
            :.:|.:..:.|:..:|...   .|...:.|:::.                             ||
Human   195 EVSEPHILETLKPATKTAELSVVSTSVISEQSEQSVAVMPEPSMTKILDSFAAAPVPTTTLVLKS 259

  Fly   523 EER------KPEAKKVRNAIENSKEAPTDRKKDKLLGPLGEKTDERSKDKQIKRSREQSVTKCPK 581
            .|.      :.:.|.|..::|::...|:   |..|:.|...|..|.|:...:.   .::.|:...
Human   260 SEPVVTMSVEYQMKSVLKSVESTSPEPS---KIMLVEPPVAKVLEPSETLVVS---SETPTEVYP 318

  Fly   582 ESGKDTLMEHPPQENGLDGSKRSSMPHE---SFSESAKTREH---------ASRRKNQTLSPWGS 634
            |....|.|:. |:.:.::..:....|.:   ..::|:.||..         |...:..:::....
Human   319 EPSTSTTMDF-PESSAIEALRLPEQPVDVPSEIADSSMTRPQELPELPKTTALELQESSVASAME 382

  Fly   635 REGTPPMTPPQVQ-IPQTPIVDIANPKDFDIFADSPPRVNTAV----SAPAATIER------STT 688
            ..|.|..:.|::| .|.||::::..|....: .:.|..::|.|    ..||..:..      :..
Human   383 LPGPPATSMPELQGPPVTPVLELPGPSATPV-PELPGPLSTPVPELPGPPATAVPELPGPSVTPV 446

  Fly   689 PPLKSSIPIVPI---------------AKADKL--APLLKA-----------------------S 713
            |.|...:|.:|.               ..|.:|  .||:.|                       :
Human   447 PQLSQELPGLPAPSMGLEPPQEVPEPPVMAQELPGLPLVTAAVELPEQPAVTVAMELTEQPVTTT 511

  Fly   714 EIHSRIGALLEESDLHLDNLLATKEQLFRRTNEYKERKEAPKEIKAEYLPNSRHNRSATGRAEVE 778
            |:...:|....|...|.:...||............|....|....|..||.   ..|.||..|  
Human   512 ELEQPVGMTTVEHPGHPEVTTATGLLGQPEATMVLELPGQPVATTALELPG---QPSVTGVPE-- 571

  Fly   779 HHKSQPRHINPFKRESVLSGRKSSSRPSSKERRFQRHDSEVENWDRDLELERNQLNGSQLTGFQP 843
                             |.|..|::|.                    |||....:....|....|
Human   572 -----------------LPGLPSATRA--------------------LELSGQPVATGALELPGP 599

  Fly   844 RKSDEYTKFSIKK----EKDLTPPPLQTNFTRTTIKIERNATPPRHMEHDVLVRNGAVATNAPPP 904
            ..:....:||.:.    ..:|...||.|..      :|....|            ||......|.
Human   600 LMAAGALEFSGQSGAAGALELLGQPLATGV------LELPGQP------------GAPELPGQPV 646

  Fly   905 AKEQESPDTDDYIDNWENDDSLASMPKNAPPVTPTPAPNANASLNATPLPPVASQFNGDDDDDDS 969
            |...........:...|......|.....|..|...:.|..|....|.|....|...|.|     
Human   647 ATVALEISVQSVVTTSELSTMTVSQSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVD----- 706

  Fly   970 NALWNAKSTPPPRRKNENLPEGNI---HELYDKFMNSIKMSNEHLEPETLDTS--KNSSLSNSPA 1029
                 ....|.......|..|.:|   :.:..:.:.|..|.::.|...|:|:.  .:|::.:...
Human   707 -----PLMAPESHILASNTMETHILASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQML 766

  Fly  1030 EESSSGTETSSTSSSSSETEDDSSSDDDANESSSNDESATTSGNCNTNQDEAAGKEQLQKKNNVS 1094
            ..||..::..:|||..|:....|:.|.....:||.|.....:.:.::         |:...:::.
Human   767 ATSSMDSQMLATSSMDSQMLATSTMDSQMLATSSMDSQMLATSSMDS---------QMLATSSMD 822

  Fly  1095 KDLRKLKSLEDNLARIQMMRENYDAGDEISEELLKMESL-FLMQRNAIMDKYRKQELKSNSSEDQ 1158
            ..:....|::..:.....|.....|...:..::|...|: ..|..:..||   .|.|.|.:.:.|
Human   823 SQMLATSSMDSQMLATSTMDSQMLATSTMDSQMLATSSMDSQMLASGTMD---SQMLASGTMDAQ 884

  Fly  1159 QPVDEQGTVQAQEVVKETSFPVNSIFSANREAIKLTISPLKLTRKSVIFDKDEADLPETSKAEPP 1223
            ...  .||:.||.:...|                                :|.|.|  .||:..|
Human   885 MLA--SGTMDAQMLASST--------------------------------QDSAML--GSKSPDP 913

  Fly  1224 KQTLQKPQKEIAIVKPTIVESRSKPKLRSPPPSSGSRRRSRSRSISRSRARRRGSRTKSRTPSPR 1288
            .:..|.|.                 :|...|...|.                             
Human   914 YRLAQDPY-----------------RLAQDPYRLGH----------------------------- 932

  Fly  1289 RRRLPSPRRVSRYAKRIGGGAVGGTRKGRSHSRSLTRSRTRSRSPSRRRRLPPAGHRKRGSISPI 1353
                 .|.|:...|.|:|....   |.|....| ||....| .|| |..|:.|..:|    |:|.
Human   933 -----DPYRLGHDAYRLGQDPY---RLGHDPYR-LTPDPYR-MSP-RPYRIAPRSYR----IAPR 982

  Fly  1354 PQKLAGPRSPPP----SRRRQSLSRDREREHLSR-SRSPLPFKPP--SPPMRRSWSKARSPTRRR 1411
            |.:||    |.|    |||...:|...||..:|. .||.:.::..  ||...||...|...:...
Human   983 PYRLA----PRPLMLASRRSMMMSYAAERSMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMS 1043

  Fly  1412 SFSRSRSRSISPRSRLSA-EEAFANYFEENQGMEAAAYYYNMSLMQQEDQNALGEGYDAYAAYMD 1475
            ::.||....::.||.:|| |.:..:.:|.:.....|    :.|:|......::...|.|....|.
Human  1044 AYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMA----DRSMMSMGADRSMMSSYSAADRSMM 1104

  Fly  1476 SAYN----------------MEQAYAQYSEEYSNTYMD-YMVEVASSPQAPGSVLRELPMAPMMP 1523
            |:|:                |..|...|::.|::||.: |||     |..|.   .|.|..|.:|
Human  1105 SSYSAADRSMMSSYTADRSMMSMAADSYTDSYTDTYTEAYMV-----PPLPP---EEPPTMPPLP 1161

  Fly  1524 VES--LAPIAPLEAMPSMAATASGMPVAVQKGNVLEIVPSGEDILEAEENIVPDATDKPVEDT-S 1585
            .|.  :.|..|.|..|...|                 :|:.:..|.||.....:....|.|:: |
Human  1162 PEEPPMTPPLPPEEPPEGPA-----------------LPTEQSALTAENTWPTEVPSSPSEESVS 1209

  Fly  1586 KPKGKGVNFVDKVLPAYESDNEDRAVVEMAVKRALRKYHESRSQAAAKLQLIRDELLLLPPPPPP 1650
            :|:.          |..:|:..:.:.|.       ..|..|.|..:.   |:.:..:.:|.|||.
Human  1210 QPEP----------PVSQSEISEPSAVP-------TDYSVSASDPSV---LVSEAAVTVPEPPPE 1254

  Fly  1651 P---LTTKPANLEKPVLVQKK---PKFRYFHFDPFKCAIVKTYTRTLRS---AYRPP-------- 1698
            |   :|..|  :|..|:.::.   |:      .|..|.:.:|...:...   |..||        
Human  1255 PESSITLTP--VESAVVAEEHEVVPE------RPVTCMVSETPAMSAEPTVLASEPPVMSETAET 1311

  Fly  1699 FDPK----HFAMLMKTGRLPQIPPGFLRHRPPFIPAHVDAVTRGAMLKEFFSKHPPPPLAMPMPV 1759
            ||..    |.|..:.|..|              :||....|...::|:       ||.:|     
Human  1312 FDSMRASGHVASEVSTSLL--------------VPAVTTPVLAESILE-------PPAMA----- 1350

  Fly  1760 PNGMPYYLSGPPPTSSGAAVSPVPVNVL-PQPIPVLDGSGYQGYPQSATMVPLPVPVPVPVPLPV 1823
                      .|.:|:.|.:....|.|| ...:.||:.|.......|...||.|..|..|..:.:
Human  1351 ----------APESSAMAVLESSAVTVLESSTVTVLESSTVTVLEPSVVTVPEPPVVAEPDYVTI 1405

  Fly  1824 PLPVSTDTTPS-PALE--TPYFTPPPLPELPPLPELPSQFTVS----SVPTITEIMPVDILQKLG 1881
            |:||.:...|| |.||  .....|..:...|.:....|..|||    :|...|:::|.::..:..
Human  1406 PVPVVSALEPSVPVLEPAVSVLQPSMIVSEPSVSVQESTVTVSEPAVTVSEQTQVIPTEVAIEST 1470

  Fly  1882 PL-----------PKTLDVDDGGGTASPE----DISDDLKEVEAKPAEQHVVG 1919
            |:           .|.:::..|....:||    :|:  |...|...||:|:.|
Human  1471 PMILESSIMSSHVMKGINLSSGDQNLAPEIGMQEIA--LHSGEEPHAEEHLKG 1521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(3)psg2NP_647974.1 PRP38_assoc 374..450 CDD:289628 22/91 (24%)
SONNP_620305.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..56 9/47 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 77..155 20/78 (26%)
PHA03247 <170..460 CDD:223021 49/297 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 305..328 4/25 (16%)
PHA03379 <340..673 CDD:223066 65/393 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 406..442 6/36 (17%)
17 X 10 AA tandem repeats of L-A-[ST]-[NSG]-[TS]-MDSQM 726..895 33/182 (18%)
MSCRAMM_SdrC <730..903 CDD:380146 35/218 (16%)
11 X 7 AA tandem repeats of [DR]-P-Y-R-[LI][AG][QHP] 912..988 28/140 (20%)
14 X 6 AA repeats of [ED]-R-S-M-M-S 1006..1126 26/123 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1144..1236 28/133 (21%)
3 X 11 AA tandem repats of P-P-L-P-P-E-E-P-P-[TME]-[MTG] 1147..1179 11/34 (32%)
rne <1289..1481 CDD:236766 49/227 (22%)
4 X 8 AA tandem repeats of V-L-E-SS-[AVT]-VT 1359..1390 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1645..1722
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1754..2054
7 X 7 AA repeats of P-S-R-R-S-R-[TS] 1925..1994
2 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-S 1934..2013
3 X tandem repeats of [ST]-P-[VLI]-R-[RL]-[RK]-[RF]-S-R 2013..2039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2200..2220
G-patch 2305..2349 CDD:396249
DSRM_SF 2369..>2419 CDD:412133
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_2BZCQ
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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