DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)psg2 and Srrm1

DIOPT Version :9

Sequence 1:	NP_647974.1	Gene:	l(3)psg2 / 38630	FlyBaseID:	FBgn0035617	Length:	1929	Species:	Drosophila melanogaster
Sequence 2:	NP_058079.2	Gene:	Srrm1 / 51796	MGIID:	1858303	Length:	923	Species:	Mus musculus

Alignment Length:	1125	Identity:	245/1125 - (21%)
Similarity:	355/1125 - (31%)	Gaps:	437/1125 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   434 TRAKSRKRSSSRDKRREKSKEKLGDKEKNEDLSKEKLE-------GKSTEHSEKR---------N 482
            |.|:...|.|::.|:..|..:.....||..|:||..||       .:.||.....         |
Mouse     9 TSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFN 73

  Fly   483 ESKVKNKDT-----------NEENANKKLRERSKDRNHSKERLHERTQNKSEERKPEAKKVRNAI 536
            :.:|||.|:           |.:||.:.:.|.......::|.:........|.:|.|.|  :..|
Mouse    74 QLEVKNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIK--QRQI 136

  Fly   537 ENSKEAPTDRKKDKLLGPLGEKTDERSKDKQIKRSREQSVTKCPKESGKDTLMEHPPQENGLDGS 601
            |..|.|..            :|.|| .|||:.|..:|.|..|                      .
Mouse   137 EQEKLASL------------KKQDE-DKDKRDKEEKESSREK----------------------R 166

  Fly   602 KRSSMPHESFSESAKTREHAS-----RRKNQTLSPWGSREGTPPMTPPQVQIPQTPIVDIANPKD 661
            :||..|....|.|...|..:|     |:::.:.||   |..|...:|
Mouse   167 ERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSP---RHRTKSRSP------------------ 210

  Fly   662 FDIFADSPPRVNTAVSAPAATIERSTTPPLKSSIPIVPIAKADKLAPLLKASEIHSRIGALLEES 726
                                    |..|..|...|.:|       .|.::..:      :.::|:
Mouse   211 ------------------------SPAPEKKEKSPELP-------EPSVRMKD------SSVQEA 238

  Fly   727 DLHLDNLLATKEQLFRRTNEYKERKEAPKEIKAEYLPNSRHNRSATGRAEVEHHKSQPRHINPFK 791
            ....|.|.|.|.:......|....|.:.|| |.:..|.||....:..|.    ....|.|..|.:
Mouse   239 TSTSDILKAPKPEPVPEPKEPSPEKNSKKE-KEKTRPRSRSRSKSRSRT----RSRSPSHTRPRR 298

  Fly   792 RESVLSGRKSSSRPSSKERRFQRHDSEVENWDRDLELERNQLNGSQLTGFQPRKSDEYTKFSIKK 856
            |      .:|.||..|..||                             ..||:
Mouse   299 R------HRSRSRSYSPRRR-----------------------------PSPRR----------- 317

  Fly   857 EKDLTPPPLQTNFTRTTIKIERNATPPRHMEHDVLVRNGAVATNAPPPAKEQESPD-------TD 914
                .|.|             |..||||.|               |||.:.:.|..       :.
Mouse   318 ----RPSP-------------RRRTPPRRM---------------PPPPRHRRSRSPGRRRRRSS 350

  Fly   915 DYIDNWENDDSLA---SMPKNAPPVTPTPAPNANASLNATPLPPVASQFNGDDDDDDSNALWNAK 976
            ..:....:..|.:   |.||..|..|.:| |.....|:.:..||......            ::.
Mouse   351 ASLSGSSSSSSSSRSRSPPKKPPKRTSSP-PRKTRRLSPSASPPRRRHRP------------SSP 402

  Fly   977 STPPPRRKNENLPEGNIHELYDKFMNSIKMSNEHLEPETLDTSKNSSLSNSPAEESS-----SGT 1036
            :||||:.::...|:               .||.         ::.|.:|.||...|.     .||
Mouse   403 ATPPPKTRHSPTPQ---------------QSNR---------TRKSRVSVSPGRTSGKVTKHKGT 443

  Fly  1037 ETSSTSSSS--------SETEDDSSSDDDANES--------SSNDESATTSGNCNTNQDEAAGKE 1085
            |...:.|.:        ||:|:|..|...|.:|        ..|.:|::.||:.:|::||.
Mouse   444 EKRESPSPAPKPRKVELSESEEDKGSKMAAADSVQQRRQYRRQNQQSSSDSGSSSTSEDER---- 504

  Fly  1086 QLQKKNNVSKDLRKLKSLEDNLARIQMMRENYDAGDEISEELLKMESLFLMQRNAIMDKYRKQEL 1150
              .|:::|                     :|.:.|                        .|::..
Mouse   505 --PKRSHV---------------------KNGEVG------------------------RRRRHS 522

  Fly  1151 KSNSSEDQQPVDEQGTVQAQEVVKETSFPVNSIFSANREAIKLTISPLKLTRKSVIFDKDEADLP 1215
            .|.|:.......::.|....::.|....||..  |:.|   :.:.||....|:.
Mouse   523 PSRSASPSPRKRQKETSPRMQMGKRWQSPVTK--SSRR---RRSPSPPPARRRR----------- 571

  Fly  1216 ETSKAEPPKQTLQKPQKEIAIVKPTIVESRSKPKLRSPPPSSGSRRRSRS---------RSISRS 1271
            ..|.|.||......|::..:   ||....|..|   ||||    ||||.|         |..|.|
Mouse   572 SPSPAPPPPPPPPPPRRRRS---PTPPPRRRTP---SPPP----RRRSPSPRRYSPPIQRRYSPS 626

  Fly  1272 RARRRGSRTKSRTPSPRRRRLPSP---RRVSR----------YAKRIGGGAVGGTRKGRSHSRSL 1323
            ...:|  ||.|..|.|:||..|||   ||||.          ..||.........|||.|..||.
Mouse   627 PPPKR--RTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSPTVTKRRSPSLSSKHRKGSSPGRST 689

  Fly  1324 TRSRT----RSRSPSRRRRLP---------------PAGHR---------KRGSISPIPQKLAGP 1360
            ..:|:    :..|||.|.|.|               |.|.:         :|.|.:|.|:|:...
Mouse   690 REARSPQPNKRHSPSPRPRAPQTSSPPPVRRGASASPQGRQSPSPSTRPIRRVSRTPEPKKIKKA 754

  Fly  1361 RSP-PPSRRRQSLSRDREREHLSRSRSPLPFKPPSPPM-------RRSWS------KARSPTRRR 1411
            .|| |.|.||.|.||.     :|.|..|...|||:||.       ..:||      ||:|||
Mouse   755 ASPSPQSVRRVSSSRS-----VSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPAKKAKSPT--- 811

  Fly  1412 SFSRSRSRSISPRSRLSAEE 1431
                   .|:|| :|.|.:|
Mouse   812 -------PSLSP-ARNSDQE 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)psg2	NP_647974.1	PRP38_assoc	374..450	CDD:289628	5/15 (33%)
Srrm1	NP_058079.2	PWI	46..115	CDD:279781	12/68 (18%)
Srrm1	NP_058079.2	Hepatitis_core	<626..717	CDD:279277	31/92 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	2	1.960