DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)psg2 and toporsa

DIOPT Version :9

Sequence 1:	NP_647974.1	Gene:	l(3)psg2 / 38630	FlyBaseID:	FBgn0035617	Length:	1929	Species:	Drosophila melanogaster
Sequence 2:	NP_001292484.1	Gene:	toporsa / 324197	ZFINID:	ZDB-GENE-030131-6401	Length:	999	Species:	Danio rerio

Alignment Length:	717	Identity:	146/717 - (20%)
Similarity:	258/717 - (35%)	Gaps:	199/717 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PEDLQDNDTNSLEPGEVVTP----PHY-HPSSPAVKKHLSKELMISKTLRKLPVSVVEQARKENG 83
            |..::|:|::| ..||.|.|    .|. ||::|                     |.::.....:.
Zfish   357 PVHVRDSDSDS-SVGEAVMPIAAVRHQDHPANP---------------------STIQPEEDHSS 399

  Fly    84 SG-------GTPNAQAEDADDSEGLYSESDSSGEDLKNVEDVQKARKEKQEEAAAATLPQAPPTP 141
            |.       |.....||...:...|.|:|::|                :.|:.|:....|||.
Zfish   400 SNDEDCVIIGYVKPVAERTPELVQLSSDSENS----------------ETEQNASPRNSQAPQ-- 446

  Fly   142 FLGINPLRFHMRAPCFEFPRMGFMPRMNRGGPRGMRPTFFGRPPAANRMGAPMMGGLPTQGPPPG 206
                     |:|          |:...:            ..|.|:.|         |.:||...
Zfish   447 ---------HIR----------FISDSD------------ASPTASQR---------PLRGPASS 471

  Fly   207 AYAPQNPPP------------TGINSNSGRCKRLQSDVIWTALQPPVSFVFNLVSECSNTKHENC 259
            :.:.::...            :|....|.:.||:.|. .....||          .|..:|::.
Zfish   472 SRSFEDTSIQLRKNSKYDNTFSGSREGSSQSKRIHSS-SHRKKQP----------LCKESKNKQ- 524

  Fly   260 RTKAETTDHNS------------KESKLPSETKST----------------------EPLIENNR 290
            |.:.||:.|:|            ...|..:||.|:                      ..|::.:|
Zfish   525 RGEKETSRHSSSYWHSYSYYSHDNSRKAYTETSSSYTSYYRSVNDQFGSRSHGKRRCRDLLDRSR 589

  Fly   291 SRELPQHKNYVRGKTSNRSHDRTQNR-----GRTRERSKESHGKSTENSKNKDEGRGKGR----- 345
            ||   .:....:....|||..|:.:|     .|.|..|:.:.|||..|.:|:...|...|
Zfish   590 SR---SNSRISQSNRRNRSRSRSNSRISRSNQRNRSHSRSNSGKSQSNRRNRSCSRSYSRTSPFN 651

  Fly   346 ERDLFRRKSRERSQDKNLNR-AKSMNLSKEKDEVGGEPRNTASGKSQERDQSRGKTKDRSRERDR 409
            ||:  ||.||..|:....|| .:|.:.|..:.....|.....|..:..:.||....:..||...|
Zfish   652 ERN--RRHSRSNSRKSQSNRHNRSCSRSYSRTSPFNERNRRHSRSNSRKSQSNRHNRSCSRSYSR 714

  Fly   410 T-----RNKTREKSQARDQTRSKANDAEHTRAKSRK-RSSSRDKRREKSKEKLG-DKEKNEDLSK 467
            |     ||:...:|.:|....|:.| ...:|:.||| .|:.|::...:|..::. ..::|...|:
Zfish   715 TSPFNQRNRRHSRSNSRISQSSRQN-RSLSRSNSRKGYSNRRNRNHSRSSSRVSQSSQRNRSHSR 778

  Fly   468 EKLEGKSTEHSEKRNESKVKNKDTNEENANKKLRERSKDRNHSKERLHERTQNKSEERKPEAKKV 532
            .....||:  |.|..:.|.:...:....:|..:|.||:    |..|::  |.::.:.|:..:...
Zfish   779 SNFRIKSS--SYKSQDEKYQRSLSRSLYSNNDVRSRSR----SSSRIN--TSSRQDRRRSRSSSR 835

  Fly   533 RNAIENSKEAPTDRKKDKLLGPLGEKTDERSK--DKQIKRSREQSVTKCPKESGKDTLMEHPPQE 595
            .|:..:.:.:..|:        .|:|...::|  :|..::|..:||....:..||....:|..:.
Zfish   836 MNSSSSRQTSCHDK--------YGKKRMYKTKHHEKPSRQSSSKSVGDSDEVGGKKKKKKHTKRR 892

  Fly   596 NGLDGSKRSSMPHESFSESAKTREHASRRKNQTLSP-WGSREGTPPMTPPQVQIPQTPIVDIANP 659
                  |..|...:..||....|.|..::|::..|. ..|:|.|..::|..:.|......:.|:|
Zfish   893 ------KTRSPSIDDRSEGHSQRHHKRKKKHKKKSKRHNSKERTRKLSPVLITITTDSDGESADP 951

  Fly   660 KD 661
            .:
Zfish   952 SE 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)psg2	NP_647974.1	PRP38_assoc	374..450	CDD:289628	20/81 (25%)
toporsa	NP_001292484.1	RING-HC_Topors	28..67	CDD:319488
		RING-HC finger (C3HC4-type)	28..66	CDD:319488
		RRM	635..>749	CDD:330708	30/116 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930