DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)psg2 and Son

DIOPT Version :9

Sequence 1:	NP_647974.1	Gene:	l(3)psg2 / 38630	FlyBaseID:	FBgn0035617	Length:	1929	Species:	Drosophila melanogaster
Sequence 2:	NP_849211.3	Gene:	Son / 20658	MGIID:	98353	Length:	2444	Species:	Mus musculus

Alignment Length:	1827	Identity:	362/1827 - (19%)
Similarity:	577/1827 - (31%)	Gaps:	524/1827 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 KSRERSQDKNLNRAKSM-----NLSKEKDEVGGEPRNTASGKSQERDQSRGKTKD-RSRERDRTR 411
            |.||..|:.:..|::..     |...|.::.|.   ..||.:|...::...|.:: .|...|...
Mouse    16 KFREIQQELSSGRSEGQLNGETNPPIEGNQAGD---TAASARSLPNEEIVQKIEEVLSGVLDTEL 77

  Fly   412 NKTREKSQARDQTRSKANDAEHTRAKSRKRSSSRDKRREKSKEKLGDKEKNEDLSKEKLEGKSTE 476
            ....:..:|..::|..:...:.|.....|:|....|.:.|.|:|..:|||......|:.|.|...
Mouse    78 RYKPDLKEASRKSRCVSVQTDPTDEVPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKLKS 142

  Fly   477 HSEKRNESKVKNKDTNEENANK--------KLRERSK--------------DRNHSKERLHERTQ 519
            |.:...||....|..:|.:|..        .|.|.|:              ..:|..|.|...|:
Mouse   143 HHDGNLESDSFLKFDSEPSAAALEHPVRAFGLSEASETALVLEPPVVSMEVQESHVLETLKPATK 207

  Fly   520 -------------NKSEE-----RKPEAKKVRNAIENSKEAPTDRKKDKLLGPLGEKTDERSKDK 566
                         .:||:     .:|...|:   :::...||.......|..|....|......|
Mouse   208 AAELSVVSTSVISEQSEQPMPGMLEPSMTKI---LDSFTAAPVPMSTAALKSPEPVVTMSVEYQK 269

  Fly   567 QIKRSREQSVTKCPKESGKDTLME-----------------------HP---------PQENGLD 599
            .:.:|.|    ..|.|:.|.||:|                       ||         |:.:..|
Mouse   270 SVLKSLE----TMPPETSKTTLVELPIAKVVEPSETLTIVSETPTEVHPEPSPSTMDFPESSTTD 330

  Fly   600 GSKRSSMPHESFSE---SAKTREHASRRKNQTLSPWGSREGT---------PPMT-------PPQ 645
            ..:....|.|:.||   |:.||...|....:|.:. ..:|.|         ||.|       ||.
Mouse   331 VQRLPEQPVEAPSEIADSSMTRPQESLELPKTTAV-ELQESTVASALELPGPPATSILELQGPPV 394

  Fly   646 VQIPQ------TPIVDIANPKDFDI--FADSPPRVNTAVSAPAATIERSTTPPLKSSIPIVPIAK 702
            ..:|:      ||:.:::.|....:  ....|..|...:..|:.|    ..|.|...:|..|...
Mouse   395 TPVPELPGPSATPVPELSGPLSTPVPELPGPPATVVPELPGPSVT----PVPQLSQELPGPPAPS 455

  Fly   703 ------ADKLAPLLKASEIHSRIGALLEESDLHLDNLLATKEQLFRR---TNEYKERKEAPKEIK 758
                  .:...|.:.|.|: |.:.|:....:|.....:....:|..:   |.|:    |.|..:.
Mouse   456 MGLEPPQEVPEPPVMAQEL-SGVPAVSAAIELTGQPAVTVAMELTEQPVTTTEF----EQPVAMT 515

  Fly   759 AEYLPNSRHNRSATG------RAEVEHHKSQPRHINPFKRESVLSGRKS-------SSRPSSKER 810
            ....|......:|||      .|.|.....||......:    |||:.|       |..||:
Mouse   516 TVEHPGHPEVTTATGLLGQPEAAMVLELPGQPVATTALE----LSGQPSVTGVPELSGLPSA--- 573

  Fly   811 RFQRHDSEVENWDRDLELERN-------QLNGSQL-TGFQPRKSDEYTKFSIKK----EKDLTPP 863
                        .|.|||...       :|.|..: ||        ..:||.:.    ..:|...
Mouse   574 ------------TRALELSGQSVATGALELPGQLMATG--------ALEFSGQSGAAGALELLGQ 618

  Fly   864 PLQTNFTRTTIKIERNATPPRHMEHDVLVRNGAVATNAPPPAKEQESPDTDDYIDNWENDDSLAS 928
            ||.|..      :|....|            ||......|.|...........:...|......|
Mouse   619 PLATGV------LELPGQP------------GAPELPGQPVATVALEISVQSVVTTSELSTMTVS 665

  Fly   929 MPKNAPPVTPTPAPNANASLNATPLPPVASQFNGDDDDDDSNALWNAKSTPPPRRKNENLPEGNI 993
            .....|..|...:.|..|....|.|....|...|.|               |...:..::...|.
Mouse   666 QSLEVPSTTALESYNTVAQELPTTLVGETSVTVGVD---------------PLMAQESHMLASNT 715

  Fly   994 HELY--------DKFMNSIKMSNEHLEPETLDTS--KNSSLSNSPAEESSSGTETSSTSSSSSET 1048
            .|.:        .:.:.|..|.::.|...|:|:.  .:|::.:.....|:..::..:||:..|:.
Mouse   716 METHMLASNTMDSQMLASNTMDSQMLASNTMDSQMLASSTMDSQMLASSTMDSQMLATSTMDSQM 780

  Fly  1049 EDDSSSDDDANESSSNDESATTSGNCNTNQDEAAGKEQLQKKNNVSKDLRKLKSLEDNLARIQMM 1113
            ...||.|.....:||.|.....:.:.::         |:...:::...:....|::..:.....|
Mouse   781 LATSSMDSQMLATSSMDSQMLATSSMDS---------QMLATSSMDSQMLATSSMDSQMLATSSM 836

  Fly  1114 RENYDAGDEISEELLKMESLFLMQRNAIMDKYRKQELKSNSSEDQQPVDEQGTVQAQEVVKETSF 1178
            .....|...:..::|...|         ||   .|.|.|.:.:.|...  .||:.||
Mouse   837 DSQMLATSSMDSQMLATSS---------MD---SQMLASGAMDSQMLA--SGTMDAQ-------- 879

  Fly  1179 PVNSIFSANREAIKLTISPLKLTRKSVIFDKDEADLPETSKAEPPKQTLQKPQKEIAIVKPTIVE 1243
               .:.|...:|..|..|    |:.|.:..         ||:..|.:..|.|.
Mouse   880 ---MLASGTMDAQMLASS----TQDSAMMG---------SKSPDPYRLAQDPY------------ 916

  Fly  1244 SRSKPKLRSPPPSSGSRRRSRSRSISRSRARRRGSRTKSRTPSPRRRRLPSPRRVSRYAKRIGGG 1308
                 :|...|...|.                                  .|.|:...|.|:|..
Mouse   917 -----RLAQDPYRLGH----------------------------------DPYRLGHDAYRLGQD 942

  Fly  1309 AVGGTRKGRSHSRSLTRSRTRSRSPSRRRRLPPAGHRKRGSISPIPQKLAGPRSPPP----SRRR 1369
            ..   |.|....| ||....|. || |..|:.|..:|    |:|.|.:||    |.|    |||.
Mouse   943 PY---RLGHDPYR-LTPDPYRV-SP-RPYRIAPRSYR----IAPRPYRLA----PRPLMLASRRS 993

  Fly  1370 QSLSRDREREHLSR-SRSPLPFKPP--SPPMRRSWSKARSPTRRRSFSRSRSRSISPRSRLSA-E 1430
            ..:|...||..:|. .||.:.::..  ||...||...|...:...::.||....::.||.:|| |
Mouse   994 MMMSYAAERSMMSSYERSMMSYERSMMSPMAERSMMSAYERSMMSAYERSMMSPMAERSMMSAYE 1058

  Fly  1431 EAFANYFEENQGMEAAAYYYNMSLMQQEDQNALGEGYDAYAAYMDSAYN---------------M 1480
            .:..:.:|.:.....|    :.|:|......::...|.|....|.|:|:               |
Mouse  1059 RSMMSAYERSMMSPMA----DRSMMSMGADRSMMSSYSAADRSMMSSYSAADRSMMSSYTDRSMM 1119

  Fly  1481 EQAYAQYSEEYSNTYMD-YMV------EVASSPQAPGSVLRELPMAPMMPVESLAPIAPLEAMPS 1538
            ..|...|::.|:::|.: |||      |..:.|..|.   .|.||.|.:|.|. .|..|..:...
Mouse  1120 SMAADSYTDSYTDSYTEAYMVPPLPPEEPPTMPPLPP---EEPPMTPPLPPEE-PPEGPALSTEQ 1180

  Fly  1539 MAATASGMPVAVQKGNVLEIVPSGEDILEAEENIVPDATDKPV----------EDTSKPKGKGVN 1593
            .|.||.      ...:....:.:||.:.:.|..:......:|:          .:||....:.|.
Mouse  1181 SALTAD------NTWSTEVTLSTGESLSQPEPPVSQSEISEPMAVPANYSMSESETSMLASEAVM 1239

  Fly  1594 FVDKVLPAYESDNEDRAVVEMAVKRALRKYHESRSQAAAKLQLIRDELLLLPPPP------PPPL 1652
            .|.:  ||.|.::   :|....|:.|:...||                 ::|..|      ...:
Mouse  1240 TVPE--PAREPES---SVTSAPVESAVVAEHE-----------------MVPERPMTYMVSETTM 1282

  Fly  1653 TTKPANLEKPVLVQKKPKFRYFHFDPFKCAIVK----------TYTRTLRSAYRPPFDPKHFAML 1707
            :.:||.|.....|..:....|....|...||.:          |.::...::...|.........
Mouse  1283 SVEPAVLTSEASVISETSETYDSMRPSGHAISEVTMSLLEPAVTISQPAENSLELPSMTVPAPST 1347

  Fly  1708 MKTGRLP-----QIPPGFLRHRP----PFIPAHVDAVTRGAMLKEFFSKHPPPPLAMPMPVPNGM 1763
            |.|...|     :|||..:...|    |.:|......|....:.|.....|.||   .|..|...
Mouse  1348 MTTTESPVVAVTEIPPVAVPEPPIMAVPELPTMAVVKTPAVAVPEPLVAAPEPP---TMATPELC 1409

  Fly  1764 PYYLSGPPPTSSGAAVSPVP--------------VNVLPQPIPVLDGSGYQGYPQSATMVPLPVP 1814
            ...:|.||     .|||.:|              |:.|...:|:|:       |..:.:.|:.:.
Mouse  1410 SLSVSEPP-----VAVSELPALADPEHAITAVSGVSSLEPSVPILE-------PAVSVLQPVMIV 1462

  Fly  1815 VPVPVPLPVPLPVSTDTTPSPALETPYFTPPPLPELPPLPELPSQFTVSSVPTITE--IMPVDIL 1877
            ....||:..|    |.....||:.....|....||:          .|.|.|.|.:  :|...|:
Mouse  1463 SEPSVPVQEP----TVAVSEPAVIVSEHTQITSPEM----------AVESSPVIVDSSVMSSQIM 1513

  Fly  1878 ---------QKLGP---LPKTL-----DVDDGGGTASPEDISDDLKEVE--------------AK 1911
                     :.|||   :.:||     :..|||      .:..||.|.|              .|
Mouse  1514 KGMNLLGGDENLGPEVGMQETLLHPGEEPRDGG------HLKSDLYENEYDRNADLTVNSHLIVK 1572

  Fly  1912 PAEQHVV 1918
            .||.:.|
Mouse  1573 DAEHNTV 1579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)psg2	NP_647974.1	PRP38_assoc	374..450	CDD:289628	14/76 (18%)
Son	NP_849211.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..58		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	79..155		18/75 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..358		12/56 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..468		14/80 (18%)
		13 X 10 AA tandem repeats of L-A-[ST]-[NSG]-[TS]-MDSQM	721..850		20/137 (15%)
		11 X 7 AA tandem repeats of [DR]-P-Y-R-[LI][AG][QHP]	907..983		28/140 (20%)
		14 X 6 AA repeats of [ED]-R-S-M-M-S	1001..1120		26/122 (21%)
		Forkhead_N	1011..1137	CDD:254796	27/129 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1141..1213		17/81 (21%)
		3 X 11 AA tandem repats of P-P-L-P-P-E-E-P-P-[TME]-[MTG]	1141..1173		10/35 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1802..2072
		7 X 7 AA repeats of P-S-R-R-S-R-[TS]	1950..2019
		2 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V-V-R-R-R-S-F-S-I-S	1959..2030
		3 X tandem repeats of [ST]-P-[VLI]-R-[RL]-[RK]-[RF]-S-R	2031..2057
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2192..2238
		G-patch	2323..2366	CDD:279867
		DSRM	2389..>2426	CDD:238007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BZCQ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900