DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(3)psg2 and Topors

DIOPT Version :9

Sequence 1:NP_647974.1 Gene:l(3)psg2 / 38630 FlyBaseID:FBgn0035617 Length:1929 Species:Drosophila melanogaster
Sequence 2:NP_598858.2 Gene:Topors / 106021 MGIID:2146189 Length:1033 Species:Mus musculus


Alignment Length:1098 Identity:218/1098 - (19%)
Similarity:352/1098 - (32%) Gaps:365/1098 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   431 AEHTRAKSRK---RSSSRDKRREKSKEKLGDK-------EKNEDLSKEKLEGKSTEHSEKRNESK 485
            ||..|.:||:   |.|.|.:....|:.:|...       ..:|.::....|.|....|.|...||
Mouse    25 AEEGRRRSRRVRLRGSCRHRPSLLSRRELASNGPAVPATASSEIMASAAKEFKMDNFSPKAGTSK 89

  Fly   486 VKN---KDTNEENANKKLRERSKDRNHSKERLH--------ERTQNKSEERKPEAKKVRNAIENS 539
            ::.   .|.:.::......:|..:.::....||        |.::||:|  .|..|:..::|.:|
Mouse    90 LQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAE--CPLCKQPFDSIFHS 152

  Fly   540 KEAPTDRKKDKLLGPL--GEKTDERSKDKQIKRSREQSVTKCPKESGKDTLMEHPPQENGLDGSK 602
            ..|..| .|:.:|.|.  |..|     :.:::|.|                             .
Mouse   153 VRAEDD-FKEYVLRPSYNGSFT-----NPEVRRFR-----------------------------Y 182

  Fly   603 RSSMPHESFSESAKTREHASRRKNQTLSPWGSREGTPPMTPPQVQIPQTPIVDIANPKDFDIFAD 667
            |::|..|..:.........|||..               |||...:....:.....|:|.||   
Mouse   183 RTTMTRERSASLYSPSSTVSRRTT---------------TPPDSGVLFEGLGISTRPRDVDI--- 229

  Fly   668 SPPRV--NTAVSAPAATIERSTTPPLKSSIPIVPIAKADKLAPLLKASEIHSRIGALLEESDLHL 730
              |:.  ..|:..|..|.|||                      |.|           ::|.|   
Mouse   230 --PQFMRQMALRGPTTTDERS----------------------LRK-----------IQEQD--- 256

  Fly   731 DNLLATKEQLFRRTNEYKERKEAP--KEIKAEYLPNSRHNRSATGRAEVEHHKSQPRHINPFKRE 793
              ::..:..|:|.....:..::..  ::|.||:.   |.|.:..       |:..|.    .|||
Mouse   257 --IINFRRTLYRAGVRVRSIEDGGRYRDISAEFF---RRNPACL-------HRLVPW----LKRE 305

  Fly   794 -SVLSGRKSSSRPSSKERRFQRHDSEVENWDRDLELERNQLNGSQLTGFQPRKSDEYTKFSIKKE 857
             :||.|                                  .:||.:...|.......|::.::.:
Mouse   306 LTVLFG----------------------------------AHGSLVNIVQHIIMSNVTRYDLESQ 336

  Fly   858 ---KDLTPPPLQ--TNFTRTTIKIERN----ATPPRHMEHDVLVRNGAVATNAPPPAKEQESPDT 913
               .||.|..|.  .:|....|...|:    |...:|..:|.            ||:.|:.|   
Mouse   337 AFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDC------------PPSSEEGS--- 386

  Fly   914 DDYIDNWENDDSLASMPKNAPPVTPTPAPNANASLNATPLPPVASQFNGDDDDDDSNALWNAKST 978
                   .:|.|:.:       ::|..|......:||:.:               ..|.|:.::.
Mouse   387 -------RSDSSVIT-------ISPDEAETQELDMNASTV---------------RQAPWDDETP 422

  Fly   979 PPPRRKNENLPEGNIHELYDKFMNSIKMSNEHLEPETLDTSKNSSLSNSPAEESSSGTETSSTSS 1043
            .|....:|     .:|......:||                     |:|..||..||..||..  
Mouse   423 GPSYSSSE-----QVHVGVSSLLNS---------------------SDSSDEELVSGGTTSQI-- 459

  Fly  1044 SSSETEDDSSSDDDANESSSNDESATTSGNC---NTNQDEAAGKEQLQKKNNVSKDLRKLKSLED 1105
            ...:|.||.::|.|    ||:|       ||   ...:..|....:|.:.::.|::|...:.:| 
Mouse   460 QGVQTNDDVNNDSD----SSSD-------NCVIVGFVKPLAERTPELVELSSDSEELGPYEKVE- 512

  Fly  1106 NLARIQMMRENYDAGDEISEELLKMESLFLMQRNAIMDKYRKQELKSNSSEDQQ----PVDEQGT 1166
             ..:.|...::|.:||.                    |..|....:|...:|:|    ..|....
Mouse   513 -TVKTQEQEQSYSSGDS--------------------DVSRASSPRSVLGKDEQMSKSHCDSDTR 556

  Fly  1167 VQA-QEVVKETSFPVNSIFSANREAIKLTISPLKLTRKSVIFDKDEADLPETSKAEPPKQTLQKP 1230
            :.: :|..:.||.|.....|:.|.  ....||.....:.....:......::.....|:...:..
Mouse   557 ISSKKEEKRSTSLPAPRDSSSTRG--DRVCSPYNHRHRKGGRSRSSDSRSQSRSGHDPRNHRKHG 619

  Fly  1231 QKEIAIVKPTIVESRSKPKLRSPPP------------------SSGSRRRSRSRSIS----RSRA 1273
            :|.:...:....||.|:|:.|....                  ||||..||||||..    |||:
Mouse   620 KKRLRNKRSRSRESSSRPRARKDKKRSRTRDSSWSRRSQTLSLSSGSTSRSRSRSSDHGKRRSRS 684

  Fly  1274 RRRG-------------------SRTKSR---TPSPRRRRL---------PSPR-RVSRYAKRIG 1306
            |.|.                   ||.|.|   ..|.|||.|         .||. |:..:::|..
Mouse   685 RNRDRYYLRNNYGSKYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRIQSFSERTN 749

  Fly  1307 GGAVGGT-------RKGRSHSRSLTRSRTRSRSPSRRRRLPPAGHRKRGSISPIPQKLAG-PRSP 1363
            ......:       .:.||.|.|..||||.|..|.|.|...|.|.||..:     :.|.| ....
Mouse   750 ARKKNHSERKYYYYERRRSRSVSSNRSRTTSAGPDRVRNEKPGGKRKYKT-----RHLEGTSEEA 809

  Fly  1364 PPSRRRQSLSRDREREHLSRSRSPLPFKPPSPPMRRSWSKARSPTRRRSFSRSRSRSI 1421
            .|:|...|..:|   .|..:|:....:|..|.....|.|..|....:|...|:||.|:
Mouse   810 QPAREFTSKGKD---SHYQKSKLDGSYKNESDSFSDSRSSDRETKHKRRRRRTRSLSV 864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(3)psg2NP_647974.1 PRP38_assoc 374..450 CDD:289628 8/21 (38%)
ToporsNP_598858.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36 5/10 (50%)
Required for DNA-binding. /evidence=ECO:0000250 52..376 81/466 (17%)
RING 103..146 CDD:238093 9/44 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 414..477 22/94 (23%)
Interaction with SUMO1. /evidence=ECO:0000250 438..654 50/273 (18%)
Sumoylation and localization to discrete nuclear foci. /evidence=ECO:0000250 438..574 39/191 (20%)
Interaction with TOP1. /evidence=ECO:0000250 457..879 103/453 (23%)
Interaction with p53/TP53. /evidence=ECO:0000250 457..731 65/310 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..692 43/219 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 713..934 44/160 (28%)
Interaction with UBE2I. /evidence=ECO:0000250 851..914 5/14 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 970..1033
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167835933
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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