DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and TACR3

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001050.1	Gene:	TACR3 / 6870	HGNCID:	11528	Length:	465	Species:	Homo sapiens

Alignment Length:	452	Identity:	135/452 - (29%)
Similarity:	209/452 - (46%)	Gaps:	52/452 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDLIEQESRLEFLPGA-----------EEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLV 56
            :.|::|...|...|.|           :..|.....:..|:..:||.|:.||.:..|||:||.:|
Human    42 LQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIV 106

  Fly    57 IWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAALLQSWNLPWFMCSFCPFVQALSVNV 121
            ||::...::||||||.::.||||:|..:..|.....|..||...|......|.|..|....:|..
Human   107 IWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFA 171

  Fly   122 SVFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERFRENNE 186
            |::::||||:||:.|||:||:.|.:...:|.:||.||:||.|.|.|..:
Human   172 SIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCL---------------- 220

  Fly   187 TYNVT-----RPFCMNKNLSDDQLQSFRYTLVFV--QYLVPFCVISFVYIQMAVRLWGTRAPGNA 244
             |:.|     |..|. ....:...|.|.|.::.:  .|..|..::...|..:.:.|||...||:.
Human   221 -YSKTKVMPGRTLCF-VQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDT 283

  Fly   245 QDSRDITLLKNKKKVIKMLIIVVIIFGLCWLPLQLYNILYVTIPEINDYHFISIVWFCCDWLAMS 309
            .|... ..||.|:||:||:||||:.|.:||||..:|.||.....::|.:.:|..|:....|||||
Human   284 CDKYH-EQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMS 347

  Fly   310 NSCYNPFIYGIYNEKFKREFNKRFAAC-FCKFKTSMDAHERTFSMHTRASSIRSTYANSSMRIRS 373
            ::.|||.||...|::|:..|.:.|..| |.|..:..:...:|...|....|  |.|..:.|...:
Human   348 STMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQS--SMYTVTRMESMT 410

  Fly   374 NLFGPARGGVNNGKPGLHMPRVHGSGANSGIYNGSSGQNNNVNGQHHQHQSVVTFAATPGVS 435
            .:|.|      |........|...:......:||.|.:|:.      ...:..:|.::|..|
Human   411 VVFDP------NDADTTRSSRKKRATPRDPSFNGCSRRNSK------SASATSSFISSPYTS 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	101/289 (35%)
		7tm_1	52..318	CDD:278431	94/272 (35%)
		PHA03216	467..>519	CDD:177558
TACR3	NP_001050.1	7tmA_NKR_NK3R	86..367	CDD:320669	106/299 (35%)
		TM helix 1	87..113	CDD:320669	12/25 (48%)
		TM helix 2	120..146	CDD:320669	9/25 (36%)
		TM helix 3	158..188	CDD:320669	12/29 (41%)
		TM helix 4	199..220	CDD:320669	10/20 (50%)
		TM helix 5	244..273	CDD:320669	5/28 (18%)
		TM helix 6	292..322	CDD:320669	17/29 (59%)
		TM helix 7	335..360	CDD:320669	11/24 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..465		10/58 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810