DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lkr and TACR1

DIOPT Version :9

Sequence 1:NP_647968.3 Gene:Lkr / 38622 FlyBaseID:FBgn0035610 Length:542 Species:Drosophila melanogaster
Sequence 2:NP_001049.1 Gene:TACR1 / 6869 HGNCID:11526 Length:407 Species:Homo sapiens


Alignment Length:316 Identity:102/316 - (32%)
Similarity:160/316 - (50%) Gaps:24/316 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 YAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQ 92
            :..||..:.|.:..|..|.:.:|:||.:|:|::...::||||||.::.|||||:..:..|.....
Human    25 FVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVN 89

  Fly    93 FQAALLQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGGI 157
            |..|:...|....|.|.|..|....:|..|::::||:|.||:.|||:||:.|.:...:|.:|..|
Human    90 FTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVI 154

  Fly   158 WMLALLFAVPFAIAFRVEELTERF-------RENNETYNVTRPFCMNKNLSDDQLQSFRYTLVFV 215
            |:||||.|.|.......|.:..|.       ...|:.|......|:.               |.:
Human   155 WVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVT---------------VLI 204

  Fly   216 QYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLCWLPLQLY 280
             |.:|..||.:.|..:.:.||.:..||::.| |....:..|:||:||:|:||..|.:||||..::
Human   205 -YFLPLLVIGYAYTVVGITLWASEIPGDSSD-RYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIF 267

  Fly   281 NILYVTIPEINDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAAC 336
            .:|....|::....||..|:....|||||::.|||.||...|::|:..|...|..|
Human   268 FLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCC 323

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LkrNP_647968.3 7tm_4 46..329 CDD:304433 94/289 (33%)
7tm_1 52..318 CDD:278431 89/272 (33%)
PHA03216 467..>519 CDD:177558
TACR1NP_001049.1 7tmA_NK1R 33..316 CDD:320668 97/299 (32%)
TM helix 1 35..59 CDD:320668 7/23 (30%)
TM helix 2 68..90 CDD:320668 7/21 (33%)
TM helix 3 106..128 CDD:320668 6/21 (29%)
TM helix 4 149..165 CDD:320668 8/15 (53%)
TM helix 5 194..217 CDD:320668 6/38 (16%)
TM helix 6 247..269 CDD:320668 10/21 (48%)
TM helix 7 284..309 CDD:320668 11/24 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 364..407
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4219
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X257
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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