DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and TACR2

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001048.2	Gene:	TACR2 / 6865	HGNCID:	11527	Length:	398	Species:	Homo sapiens

Alignment Length:	423	Identity:	119/423 - (28%)
Similarity:	187/423 - (44%)	Gaps:	78/423 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GAEEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFAD 81
            |.|........::.|:..:||.:..|..:.:|||.||.:|||::...|:||||||.:|.|||.||
Human    15 GPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALAD 79

  Fly    82 VIIGLFCIPFQFQAALLQSWNLPWFMCSFCPFVQALSVN---VSVFTLTAIAIDRHRAIINPLRA 143
            :.:..|...|.|..|   |.|:.:|..:||.|.....:.   ||::::||||.||:.||::|.:.
Human    80 LCMAAFNAAFNFVYA---SHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQP 141

  Fly   144 RPTKFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERFRENNETYNVTRPFCMNKNLSDDQ---- 204
            |.:...:|.:|.|||::||..|                          .|.|....::.||
Human   142 RLSAPSTKAVIAGIWLVALALA--------------------------SPQCFYSTVTMDQGATK 180

  Fly   205 -------------LQSFRYTLVFVQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNK 256
                         |..:...::.:.|.:|..|:...|..:.:.||....||:.....::..|:..
Human   181 CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAM 245

  Fly   257 KKVIKMLIIVVIIFGLCWLPLQLYNILYVTIPEINDYHFISIVWFCCDWLAMSNSCYNPFIYGIY 321
            ||.:|.:::||:.|.:||||..||.||.....:|..:.||..|:....|||||::.|||.||...
Human   246 KKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCL 310

  Fly   322 NEKFKREFNKRFAACFCKFKTSMDAHE--RTFSMHTRASSIRSTYANSSMRIRSNLFGPARGGVN 384
            |.:|:..|...|..|.....|..|..|  .|.|:.||.:...:         :..||
Human   311 NHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHT---------KETLF-------- 358

  Fly   385 NGKPGLHMPRVHGSGANSGIYNGSSGQNNNVNG 417
                      :.|..|.|...:|.:|:..:.:|
Human   359 ----------MAGDTAPSEATSGEAGRPQDGSG 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	95/302 (31%)
		7tm_1	52..318	CDD:278431	88/285 (31%)
		PHA03216	467..>519	CDD:177558
TACR2	NP_001048.2	7tm_4	42..>168	CDD:304433	52/154 (34%)
TACR2	NP_001048.2	7tm_1	50..307	CDD:278431	88/285 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4219
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810