Protein Alignment Lkr and SSTR2

DIOPT Version :10

• Sequence 1: NP_647968.3
• Gene: Lkr / 38622
• FlyBaseID: FBgn0035610
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_001041.1
• Gene: SSTR2 / 6752
• HGNCID: 11331
• Length: 369
• Species: Homo sapiens
• Alignment Length: 347
• Identity: 94/347 - (27%)
• Similarity: 162/347 - (46%)
• Gaps: 67/347 - (19%)

  Fly    36 ALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQFQAALLQS 100
            |:|:..|..:.|:.:.||||||:|:....:|:|:||:||.|||.||.:. :..:||......|..
Human    44 AVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELF-MLGLPFLAMQVALVH 107

  Fly   101 WNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRA----RPTKFVSKFIIGGIWMLA 161
            |.....:|.....|..::...|:|.||.::|||:.|:::|:::    ||.  .:|.|...:|.::
Human   108 WPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPR--TAKMITMAVWGVS 170

  Fly   162 LLFAVPFAIAFRVEELTERFREN---NETYNVTRP---------FCMNKNLSDDQLQSFRYTLVF 214
            ||..:|..|       ....|.|   ..:..:..|         |.:             ||.:
Human   171 LLVILPIMI-------YAGLRSNQWGRSSCTINWPGESGAWYTGFII-------------YTFI- 214

  Fly   215 VQYLVPFCVI--SFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLCWLPL 277
            :.:|||..:|  .:::|.:.|:..|.|...:.:.       |::|||.:|:.|||.:|..||||.
Human   215 LGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRK-------KSEKKVTRMVSIVVAVFIFCWLPF 272

  Fly   278 QLYNILYVTI-----PEIND-YHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRFAAC 336
            .::|:..|::     |.:.. :.|:.:       |..:|||.||.:|...::.||:.|..    .
Human   273 YIFNVSSVSMAISPTPALKGMFDFVVV-------LTYANSCANPILYAFLSDNFKKSFQN----V 326

  Fly   337 FCKFKTS-MDAHERTFSMHTRA 357
            .|..|.| .|..||:.|...::
Human   327 LCLVKVSGTDDGERSDSKQDKS 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tmA_leucokinin-like	36..329	CDD:320515	86/316 (27%)
		TM helix 1	37..63	CDD:320515	10/25 (40%)
		TM helix 2	70..95	CDD:320515	11/24 (46%)
		TM helix 3	108..138	CDD:320515	10/29 (34%)
		TM helix 4	149..170	CDD:320515	6/20 (30%)
		TM helix 5	205..234	CDD:320515	7/30 (23%)
		TM helix 6	254..284	CDD:320515	14/29 (48%)
		TM helix 7	297..322	CDD:320515	7/24 (29%)
SSTR2	NP_001041.1	7tmA_SSTR2	44..323	CDD:320637	86/316 (27%)
		TM helix 1	45..71	CDD:320637	10/25 (40%)
		TM helix 2	78..104	CDD:320637	11/26 (42%)
		TM helix 3	115..145	CDD:320637	10/29 (34%)
		TM helix 4	157..179	CDD:320637	6/23 (26%)
		TM helix 5	205..234	CDD:320637	8/42 (19%)
		TM helix 6	249..279	CDD:320637	14/29 (48%)
		TM helix 7	291..316	CDD:320637	8/31 (26%)