DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkr and prlhr2a

DIOPT Version :9

Sequence 1:	NP_647968.3	Gene:	Lkr / 38622	FlyBaseID:	FBgn0035610	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001034615.1	Gene:	prlhr2a / 654782	ZFINID:	ZDB-GENE-060209-1	Length:	370	Species:	Danio rerio

Alignment Length:	308	Identity:	96/308 - (31%)
Similarity:	168/308 - (54%)	Gaps:	19/308 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 VALLSIF-------YGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVIIGLFCIPFQ 92
            |.||..|       |..:.:|.|.||.|:::|:..|::|..|||.:|.||||:|:::...|:||.
Zfish    51 VELLQSFKPLIIPCYALVVLVGVFGNYLLLYVICQTKKMHNVTNFFIGNLAFSDMLMCATCVPFT 115

  Fly    93 FQAAL-LQSWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPTKFVSKFIIGG 156
            ...|. .:.|....|||.....:|.::|.|||||||||.:||:.|.::||:.|.:.....:::.|
Zfish   116 LAYAFNPRGWVFGRFMCYLVFLIQPVTVYVSVFTLTAIGVDRYYATVHPLKKRISVLACTYLLSG 180

  Fly   157 IWMLAL-LFAVPFAIAFRVEELTERFRENNETYNVTRPFCMNKNLSDDQLQSFRYTLVFVQYLVP 220
            ||:|:. |.|...|..:.||     |::  |.:.:...|.|.:   :.:..::.|:.:|:.|::|
Zfish   181 IWILSCGLVAPAVAHTYHVE-----FKD--EGFTICEEFWMGQ---EKERLAYAYSTLFITYVLP 235

  Fly   221 FCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLCWLPLQLYNILYV 285
            ...:...|:.::|:|.....||:...|:.......|:|..:::.:||..||:||||:.::|:|..
Zfish   236 LSALCISYLCISVKLRNCVVPGHRTQSQAEAQRARKRKTFRLVSLVVAAFGICWLPISVFNVLRD 300

  Fly   286 TIPEINDYHFISIVWFCCDWLAMSNSCYNPFIYGIYNEKFKREFNKRF 333
            ...::.|..:..::...|....||:||.|||:|...:::|:.|..|.|
Zfish   301 IDIDLIDKRYFLLIQLLCHLCGMSSSCCNPFLYAWLHDRFRAELRKMF 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkr	NP_647968.3	7tm_4	46..329	CDD:304433	88/284 (31%)
		7tm_1	52..318	CDD:278431	84/267 (31%)
		PHA03216	467..>519	CDD:177558
prlhr2a	NP_001034615.1	7tm_4	67..>276	CDD:304433	67/218 (31%)
prlhr2a	NP_001034615.1	7tm_1	75..333	CDD:278431	84/267 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134634
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910