DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lkr and Prokr1

DIOPT Version :9

Sequence 1:NP_647968.3 Gene:Lkr / 38622 FlyBaseID:FBgn0035610 Length:542 Species:Drosophila melanogaster
Sequence 2:NP_001342584.1 Gene:Prokr1 / 58182 MGIID:1929676 Length:393 Species:Mus musculus


Alignment Length:362 Identity:92/362 - (25%)
Similarity:179/362 - (49%) Gaps:25/362 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 EEEAEFERLYAAPAEIVALLSIFYGGISIVAVIGNTLVIWVVATTRQMRTVTNMYIANLAFADVI 83
            ||:....|.:.|...::.:..:   ||.:|..|||.:.|..:|..:::|.:||:.|||||.:|.:
Mouse    49 EEDVTNSRTFFAAKIVIGMALV---GIMLVCGIGNFIFITALARYKKLRNLTNLLIANLAISDFL 110

  Fly    84 IGLFCIPFQFQAALLQ--SWNLPWFMCSFCPFVQALSVNVSVFTLTAIAIDRHRAIINPLRARPT 146
            :.:.|.||:....:::  ||.....:|:...:::.:|:.||...|.||||||:.||::|||.|..
Mouse   111 VAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMK 175

  Fly   147 KFVSKFIIGGIWMLALLFAVPFAIAFRVEELTERFRENNETYNVTRPFCMNKNLSDDQLQSFR-- 209
            ...:..:|..:|.:::|.|:|  .|:...|......|..|     :.|| .:....||...:|  
Mouse   176 CQTAAGLIFLVWSVSILIAIP--AAYFTTETVLVIVERQE-----KIFC-GQIWPVDQQFYYRSY 232

  Fly   210 YTLVF-VQYLVPFCVISFVYIQMAVRLWGTRAPGNAQDSRDITLLKNKKKVIKMLIIVVIIFGLC 273
            :.||| ::::.|...::..|.:::..||....|| .|..:....|:.:::.:..|:.|:..:.||
Mouse   233 FLLVFGLEFVGPVVAMTLCYARVSRELWFKAVPG-FQTEQIRRRLRCRRRTVLGLVCVLSAYVLC 296

  Fly   274 WLPLQLYNILYVTIPE--INDYHFISIVWFCCDWLAMSNSCYNPFIY-GIYNEKFKREFNKRFAA 335
            |.|...:.|:....|.  :.:.|::: .::..:.:|||||..|...: .:.|...|  :.||...
Mouse   297 WAPFYGFTIVRDFFPSVFVKEKHYLT-AFYVVECIAMSNSMINTLCFVTVRNNTSK--YLKRILR 358

  Fly   336 CFCKFKTSMDAHERTFSMHTRASSIRSTYANSSMRIR 372
              .:::.|....:.:..:..|.:.|.:|.....:|::
Mouse   359 --LQWRASPSGSKASADLDLRTTGIPATEEVDCIRLK 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LkrNP_647968.3 7tm_4 46..329 CDD:304433 79/290 (27%)
7tm_1 52..318 CDD:278431 75/272 (28%)
PHA03216 467..>519 CDD:177558
Prokr1NP_001342584.1 7tmA_prokineticin-R 63..353 CDD:320332 81/304 (27%)
TM helix 1 64..90 CDD:320332 8/28 (29%)
TM helix 2 97..122 CDD:320332 11/24 (46%)
TM helix 3 137..167 CDD:320332 12/29 (41%)
TM helix 4 178..199 CDD:320332 5/22 (23%)
TM helix 5 229..258 CDD:320332 6/28 (21%)
TM helix 6 277..307 CDD:320332 7/29 (24%)
TM helix 7 321..346 CDD:320332 6/25 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
21.870

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